Parotid Cysts in Children Infected With Human Immunodeficiency Virus

Morales-Aguirre, José Juan; Patiño-Niño, Jaime Alberto; Mendoza-Azpiri, Mónica; Villalobos-Acosta, Claudia Patricia; Gómez-Barreto, Demóstenes; Torre, Carlos de la; Cashat-Cruz, Miguel

doi:10.1001/archotol.131.4.353

Cited by 14 publications

(13 citation statements)

References 14 publications

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“…Parotid gland enlargement is reported to occur in approximately 1% to 10% of HIV‐infected patients 1–4 . Although the differential diagnosis includes the disease processes that occur in the non‐HIV population, the enlargement is usually secondary to benign lymphoepithelial cysts (BLEC).…”

Section: Introductionmentioning

confidence: 99%

“…However, with the emergence of the HIV epidemic, the incidence of parotid gland BLEC has increased dramatically. It is now estimated to occur in 3% to 6% and 1% to 10% of HIV‐positive adults and children, respectively 1,2,7,10,12,13 . It is so unusual in the HIV‐negative population that cystic enlargement of the parotid gland is an indication for HIV testing 5,10 …”

Section: Introductionmentioning

confidence: 99%

“…The management of parotid gland BLEC in HIV‐positive children is even less concrete, with only 12 reported cases 1,2,11,18–20 . Although the incidence appears to have decreased with the widespread use of highly active antiretroviral therapy (HAART), the treatment of parotid gland BLEC in the HIV population continues to be controversial 21,22 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Benign Lymphoepithelial Cyst and a Classification System for Lymphocytic Parotid Gland Enlargement in the Pediatric HIV Population

2007

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This series equals the largest pediatric series of HIV-associated parotid gland BLEC in the English literature. One patient in our series also demonstrated PGL; there were no cases of BLEL. A classification system based on morphology is proposed to help resolve the confusion in terminology used to describe this entity. Most pediatric HIV-infected patients with parotid gland BLEC can be treated with observation and antiretroviral medication therapy. For others, who are symptomatic or more concerned about their cosmetic appearance, sclerotherapy may offer a reasonable option. Radiation therapy and surgery should be reserved for select cases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Benign Lymphoepithelial Cyst and a Classification System for Lymphocytic Parotid Gland Enlargement in the Pediatric HIV Population

2007

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“…Therefore, the discovery of parotid gland LECs in any patient should trigger an investigation into their HIV status. Any age group may be affected, and HIVrelated LECs have been reported in patients as young as 2 months of age [31,33].…”

Section: Hiv Associated Lymphoepithelial Cystsmentioning

confidence: 99%

Selected Topics on Lymphoid Lesions in the Head and Neck Regions

Greaves

Wang

2011

Head and Neck Pathol

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Lymphoid tissue located in the head and neck region include multiple regional lymph node chains as well as mucosa associated lymphoid tissue of the conjunctiva, buccal and nasopharyngeal cavities (Waldeyer's ring), and thyroid and salivary glands. This region is a rich source of antigenic stimuli including infectious agents coming from the outside environment. Many reactive conditions that affect lymphoid tissue in this region may mimic neoplasia. In fact, distinguishing between benign and malignant lymphoid proliferations in the head and neck region is a relatively frequent diagnostic challenge and in many instances, this distinction is not straightforward. It therefore behooves the practicing pathologist to be able to recognize the benign lymphoproliferative disorders that affect this region so as to effectively guide the appropriate clinical management of such patients. Kimura disease, Epstein Barr lymphadenitis, HIV associated salivary gland disease and chronic sialadenitis are benign conditions that not infrequently affect lymphoid tissue in the head and neck region and that share certain overlapping features with malignant lymphoma. In this brief review, we discuss these conditions and highlight clinicopathological features that may help distinguish them from neoplastic lymphoproliferations that may share similar features.

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“…Since then, once the diagnosis of a branchial cyst is established, HIV testing is recommended, as it can be the first presentation of HIV infection [13]. The incidence of branchial cysts is about 3-6 % in HIV-positive adults and 1-10 % in HIV-positive children [14,15]. They appear to be most common during the early phases of HIV infection [16].…”

Section: Introductionmentioning

confidence: 99%

Branchial cysts within the parotid salivary gland

et al. 2012

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Cystic lesions within the parotid gland are uncommon and clinically they are frequently misdiagnosed as tumours. Many theories have been proposed as to their embryological origin. A 20-year retrospective review was undertaken of all pathological codes (SNOMED) of all of patients presenting with any parotid lesions requiring surgery. After analysis seven subjects were found to have histopathologically proven parotid branchial cysts in the absence of HIV infection and those patients are the aim of this review. Four of the most common embryological theories are also discussed with regard to these cases, as are their management.

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Parotid Cysts in Children Infected With Human Immunodeficiency Virus

Cited by 14 publications

References 14 publications

The Benign Lymphoepithelial Cyst and a Classification System for Lymphocytic Parotid Gland Enlargement in the Pediatric HIV Population

The Benign Lymphoepithelial Cyst and a Classification System for Lymphocytic Parotid Gland Enlargement in the Pediatric HIV Population

Selected Topics on Lymphoid Lesions in the Head and Neck Regions

Branchial cysts within the parotid salivary gland

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