Parotid duct carcinoma arising in bilateral chronic sialadenitis

Abstract

It is well recognized that, in general, chronic inflammation can predispose to malignant change. There is however, to our knowledge, no previously reported association between chronic obstructive sialadenitis and salivary gland epithelial malignancy. We describe here the first reported example in the English literature of a salivary duct carcinoma arising in a parotid gland with a long history of chronic obstructive sialadenitis. It is possible that a causal relationship exists between the two conditions. If this were the case then non-surgically treated chronic obstructive sialadenitis patients may well warrent careful clinical follow-up.

Salivary Duct Carcinoma: New Developments—Morphological Variants Including Pure In Situ High Grade Lesions; Proposed Molecular Classification

“…In fact, over 60 % of patients die of disease within 5 years of the initial diagnosis, despite radical surgery and adjuvant chemo-radiotherapy [2,7]. There are no known etiologic factors, although one case was reported in a patient with long-standing chronic obstructive sialadenitis [8,9], and another in a patient with IgG4-related sclerosing disease of the parotid [10].…”

Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States

“…Furthermore, EBV has also been implicated in HIV-related sialadenitis, a chronic inflammatory condition of the salivary gland 50. Of note, chronic or autoimmune sialadenitis has been reported to precede development of salivary gland carcinoma 51-53…”

“…51 Of note, chronic or autoimmune sialadenitis has been reported to precede development of salivary gland carcinoma. [52][53][54] The increased risk of squamous cell carcinomas of both salivary gland and nasopharynx might be attributed to Short Report tobacco or alcohol use, which are common in HIV-infected people and linked to other cancers of the head and neck. 55 Also, HPV is etiologically implicated in a subset of head and neck squamous cell carcinomas, specifically those arising in the oropharynx and tonsil.…”

Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: A case report and review of the literature

“…It is possible that the long standing presence of a Warthin tumor may give rise to chronic obstructive sialadenitis in the surrounding gland. [21][22][23] Long standing chronic sialadenitis can give rise to ductal metaplasia, then dysplasia, followed by carcinoma. 24,25 Warthin tumor is boggy on physical examination because of fluid filled cystic spaces.…”