Parotid enlargement in children seropositive for human immunodeficiency virus: imaging findings.

Soberman, N; Leonidas, John C.; Berdon, Walter E.; Bonagura, Vincent R.; Haller, Jack O.; Posner, Marshal R.; Mandel, Louis

doi:10.2214/ajr.157.3.1651645

Cited by 45 publications

(26 citation statements)

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“…Enlargement of the parotid glands is a frequent occurrence, estimated at 6-10% overall incidence 3,4 and up to 30% in paediatric cases. 5 Occasionally, parotid swelling is the first sign of HIV infection in the patient.…”

Section: Introductionmentioning

confidence: 99%

“…LECs with cervical lymphadenopathy are considered to be pathognomonic for HIV infection. It has also been documented that parotid disease in HIV-1 infection has increased from 6-10% 3,4 to 51% in AIDS. 6 HIV-related parotid swellings are often bilateral, soft, painless, asymmetrical and slow growing and are associated with persistent generalized cervical lymphadenopathy.…”

Section: Introductionmentioning

confidence: 99%

“…Ultrasound imaging is already widely accepted worldwide for diagnosis of soft tissue swellings of the head and neck region and is used by some researchers for imaging the parotid glands in HIV patients. 4,[8][9][10][11][12] The relative low cost of ultrasound imaging is an important consideration for resource-constrained African countries.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic ultrasound patterns of parotid glands in human immunodeficiency virus-positive patients in Mulago, Uganda

Kabenge

Ng²,

Muyinda³

et al. 2010

Dentomaxillofacial Radiology

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Objectives: The purpose of this study was to determine sonographically, in parotid glands of human immunodeficiency virus-positive patients, the condition of glands with or without enlargement, and propose a classification system for the patterns observed using diagnostic ultrasound imaging. Methods: In this prospective clinical study, ultrasound scans were performed on 200 patients aged 4-62 years at Mulago Hospital, Uganda. Results: There were four main distinct ultrasound pathological patterns in the parotids, i.e. lymphocytic aggregations (LAs), lymphoepithelial cysts (LECs), fatty infiltration (FI) and lymphadenopathy only. There were additional subdivisions depending on the presence of echogenic foci and intraparotid lymphadenopathy. Of those patients (n 5 64) without parotid enlargement, only 8% showed normal ultrasound features, whereas 34% showed LECs and 31% showed LAs. Of those (n 5 136) with parotid enlargement, 46% showed LECs, 23% showed FI and 15% showed LAs. The overall prevalence of LECs in the study sample was 42%. LECs were multiple, mainly between 7 mm and 12 mm in diameter and 26% showed internal echogenic foci either mobile or stationary. In contrast, LAs tended to be ill-defined, less than 5 mm and were not associated with posterior acoustic enhancement. Features differentiating LAs from LECs have not been previously described. Parotid FI (lipodystrophy) was noted in patients on highly active antiretroviral therapy, who showed lesser prevalence of LECs after 12 months of treatment. Conclusions: Our study of 200 patients is probably the largest such study in the English language literature. The wide spectrum of diagnostic ultrasound patterns was categorized into four main groups (ten subgroups).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic ultrasound patterns of parotid glands in human immunodeficiency virus-positive patients in Mulago, Uganda

Kabenge

Ng²,

Muyinda³

et al. 2010

Dentomaxillofacial Radiology

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“…In some cases, enlarged salivary glands may be due to lymphoepithelial cysts. 33 At the initial stages of HIV infection, even without immunosuppression, the parotid glands (in front of the ear) can grow with no apparent cause. It is painless bilateral parotid gland enlargement without signs of infection.…”

Section: Salivary Gland Disease (Sgd) and Xerostomia (Dry Mouth) (Figmentioning

confidence: 99%

Human Immunodeficiency Virus and Oral Health

2014

IJDA

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ABSTRACT:People with human immunodeficiency virus, the virus that causes acquired immunodeficiency syndrome, are at special risk for oral health problems. Many of these problems arise because the person's immune system is weakened and less able to fight off infections. Human immunodeficiency virus-related oral conditions occur in a large proportion of patients, and frequently are misdiagnosed or inadequately treated. Dental expertise is necessary for appropriate management, but many patients do not receive adequate dental care. Oral manifestations include oral lesions and novel presentations of previously known opportunistic diseases. Careful history taking and detailed examination of the patient's oral cavity are important parts of the physical examination, and diagnosis requires appropriate investigative techniques. Early recognition, diagnosis, and treatment of human immunodeficiency virus-associated oral lesions may reduce morbidity. Likewise, awareness of the variety of oral disorders which can develop throughout the course of human immunodeficiency virus infection, and coordination of health care services between physician and dentist, should improve overall health and comfort of the patient.

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“…La pathogénèse du syndrome lipodystrophique n'est pas encore élucidée : les mécanismes par Dans notre étude, la diminution du débit salivaire était plus importante chez les PVVIH ARV naïfs. Avant l'avènement de la multithérapie, l'hypertrophie des glandes parotides a été signalée chez 5 à 10 % des PVVIH [16][17][18] et il a été corrélé avec une diminution du taux de CD4 et à un stade avancé de l'infection à VIH ou le SIDA [19]. Notre analyse n'a pas montré de relation entre le taux de lymphocytes CD4 et la diminution du débit salivaire non stimulé.…”

Section: Fig 2 Subdivision Of Patients On Arv According To the Typeunclassified

Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

Lecor

Diop

Sall

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 1er avril 2011, accepté le 16 mai 2011)Mots clés : débit salivaire / hyposalivation / VIH / traitement ARV Résumé -Introduction : L'altération de la fonction sécrétoire des glandes salivaires a souvent été associée au virus de l'immunodéficience humaine (VIH). Ces dernières années, la multithérapie associant différents antirétroviraux (ARV) est devenue la modalité de gestion de choix pour la prise en charge de l'infection à VIH. L'objectif de cette étude était d'évaluer l'effet des médicaments antirétroviraux sur la sécrétion salivaire chez des patients vivant avec le VIH. Matériel et méthodes : Une étude transversale comparative a été réalisée sur 166 patients vivant avec le VIH (dont 94 sous ARV et 72 ARV naïfs) à la clinique des Maladies infectieuses et tropicales, au CHUN de Fann (Dakar). Le débit salivaire non stimulé et le pH salivaire ont été évalués dans les deux groupes de patients. Les données ont été statistiquement analysées et exploitées en utilisant le logiciel SPSS. Résultats : Le profil sérologique des patients était largement dominé par le VIH-1 avec 87,1 %. Dans la population de patients vivant avec le VIH et sous ARV, 7,4 % présentaient une xérostomie et 5,3 % avaient une hyposialie et seule l'association thérapeutique TDF+3TC+NVP (Ténofovir + Lamivudine + Névirapine) était statistiquement associée à l'hyposialie. Par ailleurs, dans la population de patients vivant avec le VIH ARV naïfs, 20,8 % présentaient une xéro-stomie et 13,9 % une hyposialie ; le taux de lymphocytes T CD4 n'était pas corrélé à l'hyposialie. Conclusion : La fonction des glandes salivaires était beaucoup plus affectée chez les patients non traités ; est-ce à dire que le traitement ARV agit positivement sur la fonction sécrétoire des glandes salivaires ? D'autres études plus fines et sur des cohortes plus importantes devraient être envisagées pour confirmer cette tendance. Key words: salivary flow rate / hyposalivation / HIV / ARV treatmentAbstract -Assessment of salivary flow in people living with HIV receiving antiretroviral therapy. Introduction: Impaired salivary gland secretory function has often been associated with immunodeficiency virus (HIV). In last years, HAART (highly active antiretroviral therapy) has become the modality of choice for managing HIV infection. The objective of this study was to evaluate the effect of antiretroviral (ARV) drugs on salivary secretion in patients with HIV. Material and methods: A comparative cross-sectional study was performed on 166 patients living with HIV (including 94 on ART and 72 ART naive) of the Clinical Infectious and of Tropical Diseases of the CHUN Fann (Dakar). Unstimulated salivary flow rate and salivary pH were evaluated in the two groups of patient. The data were statistically analyzed using the SPSS Results: The serological profile of patients was largely dominated by HIV-1 (87.1%). 7.4% of patients living with HIV on ART, had xerostomia, and 5.3% had oligoptyalism and only the combination therapy TDF +3 TC + NVP (Tenofovir + Lamivudine + Nevirapine) was sta...

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Parotid enlargement in children seropositive for human immunodeficiency virus: imaging findings.

Cited by 45 publications

References 0 publications

Diagnostic ultrasound patterns of parotid glands in human immunodeficiency virus-positive patients in Mulago, Uganda

Diagnostic ultrasound patterns of parotid glands in human immunodeficiency virus-positive patients in Mulago, Uganda

Human Immunodeficiency Virus and Oral Health

Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

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