Parotid Ewing's sarcoma: Extra-skeletal uncommon condition

Sabr, Ayoub; Aloua, Rachid; Kerdoud, Ouassime; Slimani, Faiçal

doi:10.1016/j.amsu.2021.102304

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Surgical resection is indicated in combination with adjuvant local radiation therapy for the operative and/or localized tumors [1,9,14]. For large localized tumors, neoadjuvant chemotherapy is recommended before surgery or radiation therapy to reduce tumor size [9,10,[14][15][16]. In our case, the patient was treated with resection of the primary tumor with the aim to control the bleeding source and achieve an accurate diagnosis through histopathology.…”

Section: Discussionmentioning

confidence: 98%

“…EES belongs to the Ewing Sarcoma Family of Tumors (EFT), characterized by genetic alterations in the form of nonrandom translocation of the Ewing sarcoma gene (EWS) on chromosome 22 [10,13,14]. This leads to the ongoing triggering of the membrane IGF-1 receptor that manages tumor proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to the ongoing triggering of the membrane IGF-1 receptor that manages tumor proliferation. These tumors are characterized by their aggressive behaviour and high recurrence rate [14]. The clinical manifestations of EES are non-specific such as localized pain and/or swelling [4].…”

Section: Discussionmentioning

confidence: 99%

“…Because skeletal and non-skeletal ES share common characteristics, the clinical diagnosis of EES is challenging [3]. The diagnostic evaluation of EES is based on the histology of the surgically resected specimen so, the actual diagnosis was achieved by rectal mass histopathology [14]. In the presented case, the histopathology analysis ws key to diagnosis and showed that the tumor cells were immunopositive for Vimentin, CD99, Cyclin D1, and Bc12 and were immunonegative for CD45 (LCA), PanCK, and Desmin.…”

Section: Discussionmentioning

confidence: 99%

“…EES is treated with multi-modality therapy, including surgical excision, chemotherapy, and radiotherapy [1,2]. Surgical resection is indicated in combination with adjuvant local radiation therapy for the operative and/or localized tumors [1,9,14]. For large localized tumors, neoadjuvant chemotherapy is recommended before surgery or radiation therapy to reduce tumor size [9,10,[14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Rectal Ewing’s Sarcoma: A Case Report of An Unusual Extra-Skeletal Tumor Presentation

Saleem¹,

Muzayen²,

Alshamali³

et al. 2023

AJOS

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Introduction: Extraskeletal Ewing’s sarcoma (EES) is a rare malignant soft tissue tumor. Those aggressive mesenchymal tumors are characterized by genetic alterations of the Ewing sarcoma gene (EWS) on chromosome 22. Signs and symptoms are usually non-specific. The clinical diagnosis of EES is challenging. Case Presentation: A 31-year-old female patient presented to our hospital with rectal bleeding. Physical examination revealed a painful and erythematous bleeding rectal mass. A pelvic MRI revealed a right-sided well-circumscribed perianal mass measuring 6.8 × 6.0 cm. Surgical excision of the rectal mass was subsequently performed. The resected specimen, including the rectal mass with a pedicle from the posterior rectal wall was sent for histopathological examination. The postoperative period was uneventful. Histopathology examination was suggestive of EES of the rectum. Clinical Discussion: EES is an unusual entity of Ewing's Sarcoma Family of Tumors, which are characterized by pathognomonic translocations. The clinical features of EES include localized pain and/or swelling. Diagnosis of EES relies on histopathology and immunohistochemistry analysis. Imaging modalities such as CT, MRI, and PET/CT are crucial to evaluate EES metastasis and assess local tumor resectability. Conclusion: Due to the rare entity of EES of the rectum, we report the case of a 31-year-old female with rectal bleeding, found to be rectal Ewing’s sarcoma.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Rectal Ewing’s Sarcoma: A Case Report of An Unusual Extra-Skeletal Tumor Presentation

Saleem¹,

Muzayen²,

Alshamali³

et al. 2023

AJOS

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Primary Extraskeletal Ewing Sarcoma of the Duodenum Revealed by 18F-FDG PET/CT

Hao

Deng

et al. 2023

Clin Nucl Med

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Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review

et al. 2023

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Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of molecularly confirmed ALES of the salivary glands and explored epidemiological, clinical, radiological, pathological, and therapeutic characteristics of a population of 21 patients including a single newly reported patient from our group. We searched the English-language literature indexed in PubMed, Medline, Scopus, and Web of Science using the keyword ‘Adamantinoma-like Ewing sarcoma’ published up to June 2022. The median age at diagnosis was 46 years, and a slight female sex predilection was observed. Most tumors originated in the parotid gland (86%) and presented as a painless palpable mass with a median diameter of 3.6 cm. Metastatic dissemination was reported only in one patient (5%), and after a median follow-up of 13 months the 1-year overall survival rate was 92%. Salivary gland ALES were frequently misdiagnosed at presentation (62% of cases) and were pathologically characterized by the presence of highly monomorphic small round blue cells with infiltrative pattern and positive immunostaining for CD99 and high- and low-molecular weight cytokeratins. Epidemiological and clinical features of salivary gland ALES raise questions on the incorporation of this malignancy in the Ewing sarcoma family tumor group.

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Parotid Ewing's sarcoma: Extra-skeletal uncommon condition

Cited by 4 publications

References 8 publications

Rectal Ewing’s Sarcoma: A Case Report of An Unusual Extra-Skeletal Tumor Presentation

Rectal Ewing’s Sarcoma: A Case Report of An Unusual Extra-Skeletal Tumor Presentation

Primary Extraskeletal Ewing Sarcoma of the Duodenum Revealed by 18F-FDG PET/CT

Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review

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