Parotid gland: an unusual site of breast cancer metastasis

Rawet, Thomas; Jegannathen, A.; Soumian, Soni

doi:10.1136/bcr-2017-221842

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Our research strategy revealed a total of 88 relevant papers 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90…”

Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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Background Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (“Breast cancer”, OR “Breast carcinoma”) AND (“Metastasis” OR “Metastases”), And (“Oral soft tissues” OR “Tongue” OR “Palate” OR “Tonsil” OR “Buccal mucosa” OR “Floor of mouth” OR “Vestibule” OR “Salivary glands”). We also searched all related journals manually. The reference list of all articles was also checked. Results Our research revealed 88 relevant papers (September 1967–September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.

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Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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“… 24 , 27 The same decision is applicable to parotid metastasis of breast cancer, but attention should be paid to the protection of the facial nerve during operation. 28 , 29 For digestive system metastasis, some researchers advocated that systemic treatment should be used as a first-line clinical decision 30 and surgical resection should be applicated only when presenting with obstruction symptoms. 31 But compared with the first-line application of systemic therapy combined with local resection, the improvement of median survival time of patients is still controversial, and there is no significant difference in OS.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Prognosis of Uncommon Metastatic Breast Cancer: A Retrospective Analysis of 82 Cases

Zhang

Sun

Yau

et al. 2023

Technol Cancer Res Treat

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With the improvement of diagnostic techniques, numerous uncommon metastases derived from breast cancer were reported. However, very few studies explored the clinical characteristics and prognostic patterns of these patients. A total of 82 cases of uncommon metastatic breast cancer (MBC) registered at our hospital from January 1, 2010, to July 1, 2022, were selected for this retrospective study. The diagnoses of uncommon metastases were based on pathology, and the potential prognostic indicators (overall survival [OS], uncommon disease-free interval [uDFI], and remaining survival [RS]) were estimated. The uncommon metastases involved distant soft tissue, parotid gland, thyroid, digestive system, urinary system, reproductive system, bone marrow, and pericardium. Stepwise multivariate Cox regression analysis indicates age ≤ 35 is an independent risk factor of poor outcome of OS, uDFI, and RS in uncommon MBC patients. Meanwhile, uncommon metastasis combined with common visceral metastasis is an independent risk factor for poor RS of uncommon MBC patients, with a hazard ratio of 6.625 (95% confidence interval = 1.490-29.455, P = .013). Post hoc pairwise comparisons showed that uncommon MBC patients who developed bone-only metastasis survived longer than those concomitant with common visceral metastasis ( P = .029). Although the incidence is low, uncommon MBC may involve multiple metastatic sites. The delayed diagnosis of uncommon metastases could lead to systemic progression of the disease. However, patients who only develop uncommon metastasis have a significantly better prognosis than that of those combined with common visceral metastasis. Even for those complicated by bone-only metastasis, active treatment of bone metastases can still achieve substantially longer survival.

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“…Definitive management differs significantly however, with nasopharyngeal malignancies being more amenable to primary chemoradiotherapy, while our case was definitively treated with combined surgical and oncological treatment modalities. In addition to the nasal septum, there are numerous reports of parotid metastases arising from more unusual sites including kidney, liver, lung and breast 18–21. As a result, otolaryngology and oncology teams alike should be mindful of rarer primary sites in cases of unusual parotid tumours.…”

Section: Discussionmentioning

confidence: 99%

Intraparotid lymph node metastasis from a nasal septal carcinoma: an unusual source of the unknown primary

2020

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Metastatic disease to the parotid lymph nodes typically occurs secondary to head and neck and cutaneous squamous cell carcinomas (SCC). Nasal septal SCC is an exceedingly rare primary cancer that rarely spreads to regional lymph nodes. A 39-year-old man presented with left-sided cervical lymphadenopathy and nasal polyposis. Initial assessment suggested that he may have a head and neck SCC of unknown origin with nodal deposits in close proximity to the parotid gland. Cross-sectional imaging did not reveal the primary source. After further review of imaging and examination under anaesthetic, the primary SCC was found on the left nasal septum. The patient ultimately required a type 1 craniofacial resection and adjuvant chemoradiotherapy to treat the disease. Thorough investigation of the ‘unknown primary’ SCC including cross-sectional imaging and endoscopic examination is essential for the diagnosis of rare and unusual primary SCCs. Nasal septal SCC can be successfully managed with combined modality treatment in the form of surgical resection and chemoradiotherapy.

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Parotid gland: an unusual site of breast cancer metastasis

Cited by 5 publications

References 7 publications

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Clinical Features and Prognosis of Uncommon Metastatic Breast Cancer: A Retrospective Analysis of 82 Cases

Intraparotid lymph node metastasis from a nasal septal carcinoma: an unusual source of the unknown primary

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