Parotid Gland as a Focus of Metastasis

Conley, John; Arena, Sebastian

doi:10.1001/archsurg.1963.01310170043009

Cited by 140 publications

(92 citation statements)

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“…The surrounding skin of the frontal area and malar area, ear, temporal region, and eyelids is the most frequent cutaneous regions to metastasize to parotid area nodes. Mucosal tumors also can spread to these nodes from the lacrimal gland, the nasal fossa, the oral cavity and oropharynx, Eustachian tube, and middle ear [3][4][5][6].…”

Section: Necessary Backgroundmentioning

confidence: 99%

Deep lobe parotidectomy—why, when, and how?

Olsen

Quer

Bree

et al. 2017

Eur Arch Otorhinolaryngol

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Section: Necessary Backgroundmentioning

confidence: 99%

Deep lobe parotidectomy—why, when, and how?

Olsen

Quer

Bree

et al. 2017

Eur Arch Otorhinolaryngol

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“…In that report, parotid LN metastasis was located in the inferior parotid node in 7 cases, multiple superficial nodes in 3 cases, and in both deep and superficial nodes in 2 cases [6]. The regions of parotid LN metastases have been reported for 18 OSCC patients, as 18 extraglandular nodes and 19 intraglandular nodes (Table 1) [3,5,6]. Our patient had an intraglandular node metastasis.…”

confidence: 48%

“…The parotid LN is an uncommon site of metastasis in OSCC. To our knowledge, six papers including the present one have reported 35 cases of parotid LN metastasis from OSCC, from 1963 to 2013 [3][4][5][6][7]; these include 11 cases of tongue SCC ( Table 1). Although Harada et al reported the 5-year incidence of parotid node metastasis for OSCC patients to be 2.5% [5], it was 0.51% (1/197) in our department.…”

Section: Discussionmentioning

confidence: 84%

“…The parotid LN is an uncommon site of metastasis for oral squamous cell carcinoma (OSCC). To our knowledge, only 34 OSCC cases of LN metastasis from OSCC have been previously reported (in 5 papers), and only 10 of these cases originated from tongue SCC [3][4][5][6][7]. We present here a rare case of metastasis to the parotid LN in a patient with tongue SCC and a review of the literature.…”

Section: Introductionmentioning

confidence: 92%

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Parotid lymph node metastasis in a patient with tongue cancer

Yamagata¹,

Kanno²,

Ito³

et al. 2014

CRCM

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Parotid lymph node (LN) metastasis occurs most commonly from cutaneous squamous cell carcinoma (CSCC) of the head and neck, but rarely from oral squamous cell carcinoma (OSCC). Here, we present a rare case of metastasis to the parotid LN in a patient with tongue cancer. Although usual extent of modified radical neck dissection that includes resection of the tail of the parotid gland is below the line of the mandibular angle and the mastoid process was performed, the parotid LN metastasis occurred. The patient was treated with partial parotidectomy and chemoradiotherapy. One year and two months later, there was no evidence of local recurrence, although multiple lung metastases were observed. We also review the literature on parotid LN metastasis from OSCC.

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“…In a series of 1,500 cases of oropharyngeal squamous cell carcinoma only 0.8 % metastasized to the parotid [17]. But conversely, these tumors have been reported to represent up to 10 % of all metastatic disease at this site [18]. Our case was additionally p16 positive which added further confusion since p16 is often used as a surrogate marker for oncogenic high risk HPV.…”

Section: Discussionmentioning

confidence: 64%

Adamantinoma-Like Ewing Sarcoma Mimicking Basal Cell Adenocarcinoma of the Parotid Gland: A Case Report and Review of the Literature

Lezcano

Clarke²,

Zhang

et al. 2014

Head and Neck Pathol

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Adamantinoma-like Ewing sarcoma (AES) is a rare variant of the Ewing family of tumors that resembles classic adamantinoma of bone. AES shows epithelial differentiation and a more complex immunohistochemical expression profile with keratin and basal marker immunoreactivity and can resemble a variety of carcinomas. We report an unusual case of an AES of the parotid gland that mimicked a basal cell adenocarcinoma. Like basal cell adenocarcinoma, this AES showed a nested basaloid proliferation with peripheral palisading in tumor nests with 'basaloid' epithelial differentiation as highlighted by cytokeratin AE1/3 and p40 positivity. However, unlike most basal cell adenocarcinomas, this tumor demonstrated high grade morphology, showed no true ductal or myoepithelial component, and also showed a tendency towards neuroectodermal phenotype with focal rosette formation, CD99 and weak synaptophysin immunoreactivity. EWSR1 and FLI1 fluorescence in situ hybridization confirmed the presence of a translocation supporting the diagnosis of AES. This is the first case of AES presenting as a primary parotid mass highlighting the potential to be mistaken for primary salivary gland carcinomas, which in addition to basal cell adenocarcinoma include other basaloid tumors such as adenoid cystic carcinoma.

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Parotid Gland as a Focus of Metastasis

Cited by 140 publications

References 0 publications

Deep lobe parotidectomy—why, when, and how?

Deep lobe parotidectomy—why, when, and how?

Parotid lymph node metastasis in a patient with tongue cancer

Adamantinoma-Like Ewing Sarcoma Mimicking Basal Cell Adenocarcinoma of the Parotid Gland: A Case Report and Review of the Literature

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