Parotid Metastasis from a Gastroesophageal Carcinoma: Report of a Case

Schoneveld, Martijn; Hesp, W. L. E. M.; Teune, T M

doi:10.1159/000100922

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…Li et al described that adenocarcinoma, NOS, had an SDC-like area, seen as cribriform epithelioid glands and comedonecrosis, but these areas comprised a small proportion of the tumor cells in the definition of adenocarcinoma, NOS 10 ; therefore, this histological type might not be reliably diagnosed by histology and cytology. Metastasis in the parotid gland has been reported from cutaneous squamous-cell carcinoma, 22 malignant melanoma, 22 Merkel cell carcinoma, 22 rhabdomyosarcoma, 22 renal cell carcinoma, 23 gastric adenocarcinoma, 24 ductal breast carcinoma, 25 and basal cell carcinoma. 26 Such metastatic cancers can be diagnosed cytologically based on clinical findings, with supporting differential diagnosis using immunocytochemistry and the following antibodies: p63 is expressed in squamous-cell carcinoma and in basal cell carcinoma; AR is not expressed in gastric adenocarcinoma or in ductal breast carcinoma; HMB45 is expressed in malignant melanoma; cytokeratin 20 in Merkel cell carcinoma; vimentin in renal cell carcinoma; and desmin in rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Kawahara

Harada

Akiba

et al. 2008

Diagnostic Cytopathology

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It has been difficult cytologically to distinguish salivary duct carcinoma (SDC) from high-grade carcinoma. We investigated the microscopic cytological findings, morphometric image analyses, and immunohistochemical features of SDC, focusing on how we achieved an accurate differential diagnosis distinguishing SDC from salivary gland carcinomas with squamous differentiation. Immunohistochemical staining was performed for androgen receptor (AR), gross cystic disease fluid protein-15 (GCDFP15), mammaglobin, human gastric mucin, MUC1, MUC2, p63, and cytokeratin high molecular weight. Of the 13 cases of SDC, 9 cases showed typical cytological findings of sheet clusters with polygonal granular cytoplasm with fine chromatin. The other 4 cases showed unusual cytological findings of a pseudo-papillary cluster or scattered cells only, and the tumor cells showed coarse chromatin. Morphometric image analysis showed that the nucleus area was statistically different between SDC and salivary gland carcinomas with squamous differentiation. AR-positive expression (P = 0.008), GCDFP15-positive expression (P = 0.005) and p63-negative expression (P = 0.001) were effective as SDC-specific markers in immunohistochemistry. An accurate cytological diagnosis of SDC can be determined by immunostaining with AR, GCDFP15, and p63, based on the nuclear findings.

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Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Kawahara

Harada

Akiba

et al. 2008

Diagnostic Cytopathology

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“…Parotid metastases are also reported synchronously with the initial presentation of the patient and metachronous years after the primary diagnosis [12] as in our case, after 6 years of being disease-free. Metastases below the clavicle are mostly from renal, lung, and breast carcinoma [13]. Less commonly, metastases from primary tumors of the gastrointestinal or genitourinary tracts into the parotid are reported.…”

Section: Discussionmentioning

confidence: 99%

“…Less commonly, metastases from primary tumors of the gastrointestinal or genitourinary tracts into the parotid are reported. And anecdotal cases such as a primary urachal adenocarcinoma of the bladder [14], gastric adenocarcinoma [13], and hepatocellular carcinoma [15] were reported.…”

Section: Discussionmentioning

confidence: 99%

Metachronous, Single Metastasis to the Parotid, from Primary Breast Cancer: A Case Report and Review of the Literature

Kmeid

Kamar

Nasser

et al. 2016

Case Reports in Oncological Medicine

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Background. The parotid gland is an unusual site for metastatic disease and when metastasis occurs, it commonly originates from head and neck primaries. Spread from distant infraclavicular sites such as the breast, into the parotid, is even more unusual with very few cases reported in the literature. Case Report. We describe the case of a 65-year-old woman presenting for a rapidly enlarging right parotid mass. She had a history of an invasive ductal carcinoma of the right breast and was disease-free in the past 6 years prior to her presentation. She was thereafter diagnosed as having a solitary parotid metastasis from breast origin. A total parotidectomy was done and she was referred for adjuvant radiotherapy. Conclusion. Any parotid metastasis should be investigated, especially in patients with a prior history of cancer where the possibility of metastasis, even if improbable, should be kept in mind. Fine needle aspiration biopsy (FNAB) is the first diagnostic procedure to be done and immunocytochemistry can provide valuable information even if it is not always needed for diagnosis. Superficial parotidectomy when feasible with adjuvant radiotherapy is the preferred approach for solitary metastasis of the parotid. The prognosis, however, remains poor regardless of the treatment modality used.

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“…[5] Metastatic disease to the parotid gland is usually caused by squamous cell carcinoma of the head and neck, primarily by direct contiguous invasion. [6,7] On the other hand, parotid metastatic disease originating from distant infraclavicular sites is rare; tumor cells from such sites are thought to reach the parotid gland through the thoracic duct or the paraspinal venous plexus. [8] The majority of parotid metastasis from breast cancer reported in the literature originate from invasive ductal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Synchronous isolated ipsilateral salivary gland metastasis from a primary breast cancer – A case report

Srinivasan

2016

JST

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The most common sites of distant metastasis for breast are the lungs, liver, bones and brain. Here we report an extremely rare presentation of isolated salivary gland metastasis from primary breast cancer, indicating advanced stage of breast disease and sign of poor prognosis. The case emphasizes the need for a thorough workup for distant metastatic disease in patients diagnosed with invasive breast cancer.

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Parotid Metastasis from a Gastroesophageal Carcinoma: Report of a Case

Cited by 14 publications

References 13 publications

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation

Metachronous, Single Metastasis to the Parotid, from Primary Breast Cancer: A Case Report and Review of the Literature

Synchronous isolated ipsilateral salivary gland metastasis from a primary breast cancer – A case report

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