Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Kaspersen, Helge; Ågmo, Anders

doi:10.1007/s00213-011-2475-1

Cited by 23 publications

(19 citation statements)

References 57 publications

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“…They are effective and tolerated well but noncompliance due to slow action, low response, and plethora of side effects are generally observed [10][11][12][13][14][15][16][17] . Also they inhibit sexual behavior [18] . Therefore, there is need to develop efficacious and safer antidepressant drug.…”

Section: (Details On Page 997)mentioning

confidence: 99%

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Aswar¹,

Kalshetti²,

Shelke

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: (Details On Page 997)mentioning

confidence: 99%

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Aswar¹,

Kalshetti²,

Shelke

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…However, fluoxetine also appeared to reduce general locomotor activity and this may have confounded measures of sexual motivation. In contrast, acute paroxetine did not alter the female’s preference for spending time near the male, but after 20 days of paroxetine treatment, time near the male was reduced (Kaspersen and Agmo, 2012). …”

Section: 0 Compounds That Alter Total or Synaptic Levels Of 5-htmentioning

confidence: 87%

“…These earlier studies were influential in implicating 5-HT 1B/1D receptors in female rat lordosis behavior. However, studies with more selective compounds have not offered convincing evidence for robust effects of 5-HT 1B/1D receptor-acting drugs (Kaspersen and Agmo, 2012). …”

Section: 0 Drugs Acting At 5-ht Receptorsmentioning

confidence: 99%

“…Kaspersen and Agmo (Kaspersen and Agmo, 2012) examined the 5-HT 1B/1D receptor antagonist, GR 125743 [ N -[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(pyridin-4-yl)benzamide], in both the partner preference and in the pacing paradigms and found no effect on any component of female sexual behavior.…”

Section: 0 Drugs Acting At 5-ht Receptorsmentioning

confidence: 99%

“…There have been 3 reports of 5-HT 2A/2C receptor agents in either the partner preference or pacing paradigms. Kaspersen and Agmo (Kaspersen and Agmo, 2012) examined effects of SB 206553 in both paradigms and reported no effect with the exception of a small decline in the number of proceptive behaviors. This contrasts with the report that SB 206553 reduced the time females spent in the male’s compartment(Uphouse et al, 2005) and with the report by Nedergaard et al (Nedergaard et al, 2004) who compared the effects of DOI and MK-212 [6-chloro-2-(1-piperazinyl)pyrazine hydrochloride] as examples of preferential 5-HT 2A and 5-HT 2C receptor agonists, respectively.…”

Section: 0 Drugs Acting At 5-ht Receptorsmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacology of serotonin and female sexual behavior

Uphouse

2014

Pharmacology Biochemistry and Behavior

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In this review, first a historical perspective of serotonin’s (5-HT) involvement in female sexual behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect of drugs that increase or decrease CNS levels of 5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have negative effects on female sexual behavior while a decrease in 5-HT is associated with facilitation of sexual behavior. Studies with compounds that act on 5-HT1, 5-HT2 or 5-HT3 receptors are discussed. Most evidence indicates that 5-HT1A receptor agonists inhibit sexual behavior while 5-HT2 or 5-HT3 receptors may exert a positive influence. There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5-HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Future studies should be directed at determining if these additional components of female sexual behavior are also modulated by 5-HT.

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Animal Models for the Study of Female Sexual Dysfunction

Marson

Giamberardino

Costantini

et al. 2013

Sexual Medicine Reviews

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Introduction Significant progress has been made in elucidating the physiological and pharmacological mechanisms of female sexual function through preclinical animal research. The continued development of animal models is vital for the understanding and treatment of the many diverse disorders that occur in women. Aim To provide an updated review of the experimental models evaluating female sexual function that may be useful for clinical translation. Methods Review of English written, peer-reviewed literature, primarily from 2000 to 2012, that described studies on female sexual behavior related to motivation, arousal, physiological monitoring of genital function and urogenital pain. Main Outcomes Measures Analysis of supporting evidence for the suitability of the animal model to provide measurable indices related to desire, arousal, reward, orgasm, and pelvic pain. Results The development of female animal models has provided important insights in the peripheral and central processes regulating sexual function. Behavioral models of sexual desire, motivation, and reward are well developed. Central arousal and orgasmic responses are less well understood, compared with the physiological changes associated with genital arousal. Models of nociception are useful for replicating symptoms and identifying the neurobiological pathways involved. While in some cases translation to women correlates with the findings in animals, the requirement of circulating hormones for sexual receptivity in rodents and the multifactorial nature of women’s sexual function requires better designed studies and careful analysis. The current models have studied sexual dysfunction or pelvic pain in isolation; combining these aspects would help to elucidate interactions of the pathophysiology of pain and sexual dysfunction. Conclusions Basic research in animals has been vital for understanding the anatomy, neurobiology, and physiological mechanisms underlying sexual function and urogenital pain. These models are important for understanding the etiology of female sexual function and for future development of pharmacological treatments for sexual dysfunctions with or without pain.

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Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Cited by 23 publications

References 57 publications

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Pharmacology of serotonin and female sexual behavior

Animal Models for the Study of Female Sexual Dysfunction

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