Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Önal, Harika Topal; Yetkin, Derya; Ayaz, Furkan

doi:10.1007/s00210-023-02669-1

Naunyn-Schmiedeberg's Arch Pharmacol

2023

DOI: 10.1007/s00210-023-02669-1

|View full text |Cite

Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Harika Topal Önal,

Derya Yetkin,

Furkan Ayaz

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Servi,

Korkmaz,

Ayaz

2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Benidipine hydrochloride (BH), a medication frequently used by the hypertension patients, acts as a calcium channel blocker. However, its effects on the macrophages have not been investigated thus far. Our goal was investigating the effect of the benidipine hydrochloride to modulate the J774.2 murine macrophage cells inflammatory activity. Our results suggest that in the absence of a standard stimulating agent (LPS) BH did not stimulate the macrophages to produce pro-inflammatory IL-12p40, TNF-α, GM-CSF and IL-6 cytokines. However, when BH was administrated to the cells in the presence of LPS as stimulating agent, it reduced the production of these pro-inflammatory cytokines. Therefore, it had anti-inflammatory activity. At the clinical setting this study suggests that BH can be utilized as hypertension drug that can suppress the inflammation associated with it.

show abstract

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Servi,

Korkmaz,

Ayaz

2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages

Ayhan,

Sevin,

Karaaslan

et al. 2024

Immunol Res

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Paroxetine’s effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells

Cited by 2 publications

References 41 publications

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages

Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages

Contact Info

Product

Resources

About