Paroxysmal Irregularity Op the Heart Amd Auricular Fibrillation

Cushny, Arthur R.; Edmunds, Charles W.

doi:10.1097/00000441-190701000-00006

Cited by 36 publications

(7 citation statements)

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“…In other words, ECGs showing dominant S in V 3 and dominant R in V 4 are defined as normal rotation. Normal-rotation ECGs have an isoelectric transitional zone in between V 3 and V 4 , which was found in the majority of cases. Additional ECG findings (http://www.sph.umn.edu/epi/ecg/ mncode.pdf) 27 that we examined were mild Q-wave abnormality (MC 1-3), frontal plane QRS axis deviations (MC 2-1, 2-2, 2-3), high R wave (MC 3-1 to 3-4), ST depression (MC 4-1 to 4-4), T-wave abnormality (MC 5-1 to 5-5), combination of high R plus either ST depression or T abnormality, first-or second-degree atrioventricular block (MC 6-2 or 6-3), intraventricular conduction disturbances (bundle-branch block) other than left bundle-branch block (MC 7-2-1 to 7-8), ventricular premature beats (MC 8-1-2), AF (MC 8-3), sinus tachycardia (MC 8-7), sinus bradycardia (MC 8-8), low QRS voltage (MC 9-1), ST elevation (MC 9-2), tall P wave (MC 9-3-1), and long P wave (MC 9-3-2).…”

Section: Biochemical and Baseline Examinationsmentioning

confidence: 96%

Prognostic Values of Clockwise and Counterclockwise Rotation for Cardiovascular Mortality in Japanese Subjects

et al. 2012

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Section: Biochemical and Baseline Examinationsmentioning

confidence: 96%

Prognostic Values of Clockwise and Counterclockwise Rotation for Cardiovascular Mortality in Japanese Subjects

et al. 2012

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“…Vulpian, Krehl, and Hering were initial proponents of the notion that such irregularities resulted from the defective mechanical output of the atria [5,6,7]. The translational research of Cushny and Edmunds provided the first direct validation of this hypothesis when in 1907 they correlated chance observations of atrial delirium made in the dog laboratory with clinical recordings of pulsus irregularis et inaequalis perpetuus [8].…”

Section: Historical Perspectivementioning

confidence: 99%

Voltage-Independent Calcium Channels, Molecular Sources of Supraventricular Arrhythmia

Wolkowicz¹,

Umeda²,

Urthaler³

et al. 2013

Atrial Fibrillation - Mechanisms and Treatment

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Since its identification over one hundred years ago, atrial fibrillation has been shown to occur frequently in the general population and is now recognized as an important medical problem in developed societies. Three major hypotheses to explain cardiac rhythm disorders like atrial fibrillation have been proposed during this time and one of these three, impulse reentry has become predominate. The two other explanations, designated as focal source hypotheses, have been relegated to a secondary role in understanding arrhythmia. Despite widespread acceptance of the reentry hypothesis, however, current noninvasive anti-arrhythmic drugs based on this mechanism poorly prevent or reverse atrial fibrillation or other types of arrhythmia. One interpretation of this paradoxical clinical result is that mechanisms other than reentry initiate arrhythmias like atrial fibrillation in real-life settings. As a consequence, current non-invasive therapeutics may neither target nor effectively suppress important but unrecognized non-reentrant mechanisms that provoke clinical arrhythmia. We have found that challenging isolated non-automatic left atrial muscle, left ventricular papillary muscle, and perfused heart in sinus rhythm with an activator of the voltage-independent Orai calcium channels provokes high frequent tachycardia and fibrillation. Thus the Orais and related voltage-independent calcium channels may be unexpected sources of arrhythmia. This manuscript provides a a synopsis of the identification of atrial fibrillation as a clinical entity, b an overview of the development of the three current hypotheses for arrhythmia, and c our hypothesis that dysregulated voltage-independent calcium channels may be a fourth means to provoke electrical instability in heart muscle.

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“…Within 5 years of Einthoven's invention of the string galvanometer, the instrument was used in clinical cardiology. Thus, in 1907, Cashny and Edmunds reported their ECG findings in paroxysmal tachycardia and atrial fibrillation (11). Two years later, another report on atrial fibrillation and its occurrence was published by Lewis (12), who in 1911, published a textbook on the mechanism of the heart beat; he dedicated his book to Einthoven (13).…”

Section: Implications Of Einthoven's Discovery Of Ecgmentioning

confidence: 99%

Nobel Prize to Willem Einthoven in 1924 for the discovery of the mechanisms underlying the electrocardiogram (ECG)

Zetterström¹

2009

Acta Paediatrica

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Paroxysmal Irregularity Op the Heart Amd Auricular Fibrillation

Cited by 36 publications

References 0 publications

Prognostic Values of Clockwise and Counterclockwise Rotation for Cardiovascular Mortality in Japanese Subjects

Prognostic Values of Clockwise and Counterclockwise Rotation for Cardiovascular Mortality in Japanese Subjects

Voltage-Independent Calcium Channels, Molecular Sources of Supraventricular Arrhythmia

Nobel Prize to Willem Einthoven in 1924 for the discovery of the mechanisms underlying the electrocardiogram (ECG)

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