Paroxysmal Nocturnal Hemoglobinuria Presenting as Acute Renal Failure

Haemolysis, Acute Renal Failure and Haemolytic-Uraemic Syndrome

“…Having read the letter by Mijares et al [1], we agree with the conclusion that acute renal failure is due to tubulo-necrosis during haemolysis.…”

Hemolysis-Induced Acute Renal Failure in Paroxysmal Nocturnal Hemoglobinuria

“…Dear Sir, Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder characterized by chronic intra vascular hemolysis and episodes of hemoglo binuria [1][2][3]. Acute renal failure (AKb) as a complication of PNH is uncommon and usually related to venous thrombosis [2,3].…”

“…Acute renal failure (AKb) as a complication of PNH is uncommon and usually related to venous thrombosis [2,3]. ARF due to acute tubular necrosis (ATN) during hemolysis or hemoglobinuria in PNH has been rarely reported [3,4], We describe a patient with PNH who developed such a complication and fully recovered on conser vative treatment alone, without dialysis.…”

“…PNH and ARF due to hemoglobinuria have been rarely reported [2,3] and are often fatal [6,7]. The pathogenesis of ARF due to intravascular hemolysis is not well under stood.…”