2023
DOI: 10.1002/viw.20230066
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PARP inhibitor rescues hearing and hair cell impairment in Cx26‐null mice

Xiaohui Wang,
Sen Chen,
Yue Qiu
et al.

Abstract: GJB2 (encoding connexin26, Cx26) mutation is the most common genetic cause of hereditary deafness. Cochlear sensory hair cell (HC) death is the core pathologic phenomenon of GJB2‐related deafness. However, mechanism‐based therapy is still obscure. A targeted‐cell conditional Gjb2 knockout mouse model was established in which the Cx26 in Deiters cells and pillar cells were knocked out at birth. We explored the mechanism of HC death caused by deficiency of GJB2 in supporting cells (SCs), which exhibited moderate… Show more

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