PARP10 Влияет На Пролиферацию Клеток Колоректального Рака: Предварительное Исследование

Wu, C. F.; Xiao, Ming; Wang, Y. L.; Threadgill, M. D.; Li, Meng; Tang, Y.; Lin, X.; Yang, L.; Li, Q. S.; Li, X.

doi:10.31857/s0026898420020184

Cited by 5 publications

(1 citation statement)

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“…MARylation has been shown to be involved in different pathophysiological processes, such as signal transduction, gene transcription, stress response, DNA damage repair and apoptosis, 4,5,8 by regulating the interaction of the target with other molecules or changing the activity of the target if the target is an enzyme. Due to the limitations of technology, previous studies on the role of MARylation in CRC were mainly focused on various enzymes, [9][10][11] which could not identify the specific modification targets. However, it has been determined that nonenzymatic proteins, DNA and RNA can undergo MARylation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

Wang¹,

Li²,

Xiao³

et al. 2021

CMAR

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Background: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer. Methods: Immunohistochemistry was used to investigate the level of mono-ADPribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed. Results: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor. Conclusion: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

Wang¹,

Li²,

Xiao³

et al. 2021

CMAR

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Identification of diagnostic biomarkers for idiopathic pulmonary hypertension with metabolic syndrome by bioinformatics and machine learning

Huang

Shen

et al. 2023

Sci Rep

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Idiopathic pulmonary hypertension (IPAH) is a condition that affects various tissues and organs and the metabolic and inflammatory systems. The most prevalent metabolic condition is metabolic syndrome (MS), which involves insulin resistance, dyslipidemia, and obesity. There may be a connection between IPAH and MS, based on a plethora of studies, although the underlying pathogenesis remains unclear. Through various bioinformatics analyses and machine learning algorithms, we identified 11 immune- and metabolism-related potential diagnostic genes (EVI5L, RNASE2, PARP10, TMEM131, TNFRSF1B, BSDC1, ACOT2, SAC3D1, SLA2, P4HB, and PHF1) for the diagnosis of IPAH and MS, and we herein supply a nomogram for the diagnosis of IPAH in MS patients. Additionally, we discovered IPAH's aberrant immune cells and discuss them here.

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Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

Gan

Sha

Zou

et al. 2022

Front. Cell Dev. Biol.

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ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer.

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PARP10 Влияет На Пролиферацию Клеток Колоректального Рака: Предварительное Исследование

Cited by 5 publications

References 0 publications

Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

Identification of diagnostic biomarkers for idiopathic pulmonary hypertension with metabolic syndrome by bioinformatics and machine learning

Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

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