Parquetina nigrescens leaves: chemical profile and influence on the physical and biochemical indices of sexual activity of male Wistar rats

Brysocarpus coccineus(Schum & Thonn) root reinstates sexual competence and testicular function in paroxetine-induced sexual dysfunction in male Wistar rats

“…In this study, the higher MF and IF, the lowered EF and the prolonged ML, IL, EL and PEI in the male rats after paroxetine treatment are indications of sexual behaviour inhibitory effects of the drug and induction of sexual dysfunction in the male rats. The minimum change of 25% on all the male sexual behaviour parameters indicate that the animals have not only been induced with sexual dysfunction but have also satisfied the minimum requirements for the male rats to be declared as having sexual dysfunction (Kayode & Yakubu, ; Malviya et al., ). The most appreciable reduction of 86.16% on EF by paroxetine suggests that the number of ejaculation was the most affected by the drug.…”

“…In male rats, sexual behaviour or sexual competence is evaluated by assessing both the number and temporal display of mounts, intromissions and ejaculations when paired with receptive (oestrus or ovariectomised) female rats (Agmo, ; Kayode & Yakubu, ; Yakubu & Jimoh, ). Drugs and plant extracts can thus be tested to determine their beneficial or detrimental effects on the frequencies and latencies of these male sexual behaviour parameters.…”

“…Baseline testing can be used to determine the sexual endophenotype of the experimental animal prior to testing the effects of the chemical compound(s) and plant extract to prevent the use of none or irregular copulators in studies of this nature (Agmo, ). In addition, baseline testing can also be used to ascertain the status of sexual dysfunction and if the sexual dysfunction has been induced in the animals (Kayode & Yakubu, ; Yakubu & Jimoh, ). In this study, the higher MF and IF, the lowered EF and the prolonged ML, IL, EL and PEI in the male rats after paroxetine treatment are indications of sexual behaviour inhibitory effects of the drug and induction of sexual dysfunction in the male rats.…”

“…Powmax M, a polyherbal drug used in the treatment of male impotence, elicits a revolutionary male sexual stimulant effects via several mechanisms like enhancing antioxidant activity, boosting the production of nitric oxide, relaxing blood vessels and increasing the testosterone content of the animals (Ajiboye et al., ; Kayode & Yakubu, ). Although the serotonin content of the animals was not evaluated in this study, the authors propose among others that the component of AEBCR might have restored sexual competence in the paroxetine‐induced sexual dysfunction male rats by signalling the cells to slow down serotonin synthesis or blocking specific serotonin receptors.…”

“…Paroxetine‐induced sexual dysfunction model was used in the present investigation because of its wide acceptability for studying the potency of medicinal plants and its natural products (Ajiboye, Nurudeen, & Yakubu, ; Allouh, Daradka, Al Barbarawi, & Mustafa, ; Malviya, Jain, Gupta, & Vyas, , ; Sabiu, Ajani, Bamishile, & Yinusa, ). Similarly, Powmax M was also adopted as a positive control in the current investigation because apart from being one of the pharmacologically approved herbal drugs in Nigeria that has brought relief to some of the inhabitants on cases relating to sexual dysfunction, it is a non‐orthodox herbal drug that has been reported to restore all the components of sexual activity in male rats (Ajiboye et al., ; Kayode & Yakubu, ; Sabiu et al., ). In addition, the use of Powmax M in this study will form the basis of comparing the efficacy of the extract of B. coccineus root with a polyherbal formulation.…”