Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis

Abstract

Pars-plana vitrectomy led to regression of CME in 59% of cases and to subsequent improvement of VA in 50% of eyes with intermediate uveitis. PPV should be considered soon after medical therapy has been shown to be ineffective.

Vitrectomy for juvenile uveitis: prognostic factors for the long-term functional outcome

“…This finding is in line with previously published reports in adults. 4,6 With the present regression model, 44% (coefficient of determination, R 2 ¼ 0.44) of the variation of the final logMAR acuity is thereby explained. The remaining part of the variation must be explained by other unknown individual patient factors.…”

“…17,18 Several studies with adult patients showed a greater variation of the CME regression rate (32.4-82.4%). [4][5][6]9,10,12 The abovementioned meta-analysis showed a regression rate of 47.4% after PPV. 23 This fact may suggest a better inflammatory CME resolution rate in paediatric patients than in adults after PPV.…”

“…There is evidence from numerous studies that PPV can lead to an improvement in visual acuity and reduce CME, and uveitic exacerbations. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] There are only three reports focusing on therapeutic PPV in a paediatric population (in total 43 eyes) with chronic uveitis. [17][18][19] All three groups reported a postoperative improvement in visual acuity, a CME reduction, and reduced rate of recurrences with a subsequently achieved reduction of the immunomodulatory therapy after follow-up times of 6 months to 10 years.…”

Long-term evaluation of dexamethasone intravitreal implant in vitrectomized and non-vitrectomized eyes with macular edema secondary to non-infectious uveitis

“…Median CRT (95% CI) was 591.8 microns (234.5; 949) in non-PPV eyes and 557.3 microns (264.6; 850) in PPV eyes at baseline; its maximum decrease was at first month, 340.6 microns (18.5; 662.7) and 327.4 microns (44.8; 610), respectively, ( Table 2) and this improvement was maintained in both groups during 5 [5,6]; N = 19 (5-7) 5 [5,6]; N = 10 (5-7) 5 [5,6]; N = 9 (5-7) 0. Eye the entire follow-up.…”

“…2,3 In addition, some studies advocate performing pars plana vitrectomy in patients with uveitic ME as a therapeutic procedure if more conservative measures failed. [4][5][6] A consequence of pars plana vitrectomy is that some intravitreal pharmacological treatments may have a reduced half-life in vitrectomized (PPV) eyes, possibly as a result of increased clearance. 6 This decreased duration of effect may lead to a need for more frequent injections.…”