Part II: Breakthroughs in Tumor-Seeking Bacteria

Lawrenz, Hannah Martin

doi:10.2144/000114625

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Nontyphoidal Salmonella: a Model For Cancer Therapy1

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2019

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“…A number of recent reviews have illustrated this role of Salmonella quite elaborately (Wang et al . ; Hernandez‐Luna and Luria‐Perez ; Lawrenz ). It has been hypothesised that the release of various pro‐inflammatory factors of bacterial pathogen‐associated molecular patterns triggers the antitumour activity of S .…”

Section: Nontyphoidal Salmonella: a Model For Cancer Therapymentioning

confidence: 99%

Nontyphoidal Salmonella : a potential anticancer agent

et al. 2019

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Summary Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella.

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Section: Nontyphoidal Salmonella: a Model For Cancer Therapymentioning

confidence: 99%