Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling

Yao, Yizhu; Song, Lanlan; Zuo, Ziyi; Chen, Zhili; Wang, Yijia; Cai, Haijian; Gu, Yanting; Lv, Zhanghang; Guan, Jiale; Chen, Rujie; Wang, Boxiang; Yang, Lehe; Huang, Xiaoying; Wang, Liangxing

doi:10.1016/j.phymed.2024.155976

Phytomedicine

2024

DOI: 10.1016/j.phymed.2024.155976

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Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling

Yizhu Yao,

Lanlan Song,

Ziyi Zuo

et al.

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2024

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Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review

Kashkooe,

Jalali,

Zarshenas

et al. 2024

Biomedicines

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The traditional use of Tanacetum parthenium (L.) Sch.Bip., commonly known as feverfew, extends across various medical conditions, notably those associated with pain and inflammation. In alignment with the growing trend towards developing medications that target specific signaling pathways for enhanced efficacy and reduced side effects, extensive research has been conducted to investigate and validate the pharmacological effects of feverfew. Among its bioactive compounds, parthenolide stands out as the most potent, categorized as a germacranolide-type sesquiterpene lactone, and has been extensively studied in multiple investigations. Significantly, the anti-inflammatory properties of feverfew have been primarily attributed to its capacity to inhibit nuclear factor-kappa B (NF-κB), resulting in a reduction in pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α). Furthermore, the anticancer properties of feverfew have been associated with the modulation of Mitogen-Activated Protein Kinase (MAPK) and NF-κB signaling pathways. This study further delves into the neuroprotective potential of feverfew, specifically in the management of conditions such as migraine headaches, epilepsy, and neuropathic pain through various mechanisms. The core objective of this study is to elucidate the phytochemical composition of feverfew, with a particular emphasis on understanding the molecular mechanisms and examining the signaling pathways that contribute to its pharmacological and therapeutic effects. Additionally, the safety, toxicity, and potential adverse effects of feverfew are comprehensively evaluated, with an overarching goal of providing valuable insights into the plant’s potential for targeted and effective treatments.

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Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review

Kashkooe,

Jalali,

Zarshenas

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling

Cited by 1 publication

References 27 publications

Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review

Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review

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