Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone

Paulsen, Evy; El-Houri, Rime Bahij; Andersen, Klaus Ejner; Christensen, Lars Porskjær

doi:10.1111/cod.13043

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…Independently from exposure via herbal remedies, that is, including also sensitisation to the vital plant(s), 4% of 13,139 patients patch tested in Odense, Denmark, were allergic to Compositae, again confirming this family of plants being the most important sensitisers in Europe [277]. Interestingly, "biodynamic" or "organic" milk, but not conventionally processed milk, may contain traces of parthenolide, most likely owing to Tanacetum vulgare L. being grazed by the cattle; although the concentrations of around 0.05-0.07 ppm are low, they might suffice to elicit ACD by skin contact with milk in the most exquisitely sensitised [278].…”

Section: Woods Plants and Plant-derived Materialsmentioning

confidence: 82%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Section: Woods Plants and Plant-derived Materialsmentioning

confidence: 82%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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“…Unabhängig von der Exposition durch pflanzliche Heilmittel, also einschließlich von Sensibilisierungen gegen vitale Pflanzen, reagierten von 13.139 Patienten, die in Odense, Dänemark, Epikutantests unterzogen wurden, 4 % allergisch auf Compositae, was wiederum bestätigt, dass diese Pflanzenfamilie zu den wichtigsten Sensibilisatoren in Europa zählt [277]. Interessanterweise kann „biodynamisch erzeugte“ oder „Bio“-Milch – nicht aber konventionell erzeugte Milch – Spuren von Parthenolid enthalten, höchstwahrscheinlich nachdem die Rinder auf der Weide Tanacetum vulgare L. gefressen haben – die Konzentrationen sind mit etwa 0,05–0,07 ppm zwar niedrig, könnten aber ausreichen, um bei besonders stark sensibilisierten Personen durch Hautkontakt mit der Milch eine ACD auszulösen [278].…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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“…▶ Table 1 provides a selected overview of sensitizing plant compounds and prevalence data. Apart from direct contact with plants/extracts mentioned above, even not so obvious routes of contact with sensitizing plant compounds may play a role in the development of skin reactions in extremely sensitive patients, as recently shown for the highly sensitizing sesquiterpene lactone (SL) parthenolide, occurring in plants of the Asteraceae family, which was found in Danish biodynamic and organic milk [12].…”

Section: Introductionmentioning

confidence: 99%

Plant Allergen-Induced Contact Dermatitis

2019

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Although manifold beneficial effects of plant compounds for the treatment of skin disorders are known, cutaneous exposure to plants can also result in various types of incompatibility reactions such as contact dermatitis. In this mini-review, we briefly describe the different clinical forms of contact dermatitis (photoinduced, irritative, and allergic form) and highlight recent publications in the field of contact dermatitis. Major topics are recent recommendations regarding testing for plant contact dermatitis, advances in understanding the immunological mechanisms of plant contact dermatitis, and case reports for plant contact dermatitis. Unfortunately, most people still associate the terms “healthy and safe to use” with plant compounds due to their natural origin, leading to an increased utilization, be it for home-made remedies or as cosmetics. Therefore, it is on the one hand important to raise awareness in a broad audience that plants may cause contact dermatitis and on the other hand to indicate to clinicians that plants should be included in a patch test if a history of plant exposure exists.

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Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone

Cited by 9 publications

References 31 publications

Contact Allergy—Emerging Allergens and Public Health Impact

Contact Allergy—Emerging Allergens and Public Health Impact

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Plant Allergen-Induced Contact Dermatitis

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