“…In this report, we present a female child with intrauterine and postnatal growth restriction, congenital heart defect and skeletal anomalies.CMA revealed a possible de novo deletion of approximately 2.1 Mb at 15q26.3. Deletions of 15q26 region have been rarely described in the literature in patients with intrauterine and/or postnatal growth retardation, intellectual disability, congenital heart defects, skeletal anomalies, eye anomalies, and dysmorphic facial features(Bellucco et al, 2021;Benbouchta et al, 2021;Choucair et al, 2015;Fan et al, 2018;Lindstrand et al, 2019;Roberts et al, 2014;Sansovic et al, 2017;Szabo et al, 2018;Tewari et al, 2017;van Duyvenvoorde et al, 2014;Xu et al, 2014;Yu et al, 2011). Haploinsufficiency of IGF1R is thought to be contributing to growth restriction, intellectual disability, facial dysmorphism, and skeletal anomalies(Walenkamp et al, 2019), whereas loss of function variants in NR2F2 have been postulated to be contributing to the congenital heart defect(Matsunami et al, 2018;Upadia et al, 2018).…”