Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress

“…Recently, yokukansan was found to ameliorate abnormal interaction behaviors, such as enhanced aggressive behavior and decreased social behavior induced by para (p)-chloroamphetamine (PCA), which is well-known to be a potent serotonergic neurotoxin . In addition, an in vitro binding assay showed that yokukansan possesses a partial agonistic effect on 5-HT 1A receptors (Terawaki et al, 2010). These reports suggest that the effectiveness of yokukansan on impaired social interaction behaviors in PCA-injected rats may be mediated through the serotonergic neuronal systems via 5-HT 1A receptors.…”

“…Yokukansan ameliorated aggressive behavior induced by a potent serotonergic neurotoxin via 5-HT 1A receptors ). Furthermore, yokukansan had a partial agonistic effect on 5-HT 1A receptors in an in vitro binding assay (Terawaki et al, 2010). It is reported that 5-HT 1A receptor agonists, including buspirone, did not induce anxiolytic effects in the EPM test (Klint 1991;Cao and Rodgers 1997).…”

“…2060054010) was donated and manufactured by Tsumura & Co. (Tokyo, Japan) according to the formulation previously reported by Terawaki et al (2010), which was used in the present studies. In brief, yokukansan is a dried extract of the following raw materials:4.0 parts Atractylodis Lanceae Rhizoma (rhizome of Atractylodes lancea De Candolle, Compositae), 4.0 parts Poria (sclerotium of Poria cocos Wolf, Polyporaceae), 3.0 parts Cnidii Rhizoma (rhizome of Cnidium officinale Makino, Umbelliferae), 3.0 parts Angelicae Radix (root of Angelica acutiloba Kitagawa, Umbelliferae), 2.0 parts Bupleuri Radix (root of Bupleurum falcatum Linne, Umbelliferae), 1.5 parts Glycyrrhizae Radix (root and stolon of Glycyrrhiza uralensis Fisher, Leguminosae), and 3.0 parts Uncaria Uncis Cum Ramulus (hook of Uncaria rhynchophilla Miquel, Rubiaceae).…”

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

“…Subsequent in vitro binding studies showed that yokukansan had a partial agonistic effect on 5-HT1A receptors, which was attributed to GM in Uncaria hook, a galenical constituent of yokukansan (Terawaki et al 2010;Nishi et al 2010). If GM is an active compound, it must be absorbed into the blood from the intestinal tract and then cross the BBB.…”

Systematic Review: Effects of the Kampo Formula Yokukan-San-Ka-Chimpi-Hange on Behavioral and Psychological Symptoms of Dementia

“…With regard to the 5-HT nervous system, a partial antagonist effect on 5-HT1A receptors [19] and a down regulation effect on 5-HT2A receptors [20] is currently being clarified; with regard to the glutamic acid nervous system, an inhibiting effect on the release of glutamic acid [21], a stimulating effect on glutamic acid transporters [22], and a protective effect on nerve cells [23] are being clarified. KB-83 is obtained by adding dried citrus peel and pinellia tuber to YKS, and is speculated to produce effects that are due to this addition.…”