2006
DOI: 10.3748/wjg.v12.i18.2895
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Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells

Abstract: Partial Beclin 1 silencing aggravates mitochondrial permeabilization and apoptosis in HepG2 cells treated with an anti-Fas antibody or with doxorubicin.

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Cited by 32 publications
(37 citation statements)
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“…Furthermore, the relative levels of cyclin d1, cdK4, Bcl-2 and Bcl-xl in Beclin 1-silenced cells were also comparable to those in control cells, accompanied by very low levels of active caspase-3 in both groups of cells. These data are consistent with previously reported results (19), and indicate that the knockdown of Beclin 1 expression did not significantly affect hepatoma cell proliferation and spontaneous apoptosis. However, our data were in disagreement with the finding that the partial downregulation of Beclin 1 expression augmented the apoptosis of HepG2 cells in vitro (19).…”
Section: Discussionsupporting
confidence: 94%
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“…Furthermore, the relative levels of cyclin d1, cdK4, Bcl-2 and Bcl-xl in Beclin 1-silenced cells were also comparable to those in control cells, accompanied by very low levels of active caspase-3 in both groups of cells. These data are consistent with previously reported results (19), and indicate that the knockdown of Beclin 1 expression did not significantly affect hepatoma cell proliferation and spontaneous apoptosis. However, our data were in disagreement with the finding that the partial downregulation of Beclin 1 expression augmented the apoptosis of HepG2 cells in vitro (19).…”
Section: Discussionsupporting
confidence: 94%
“…These data are consistent with previously reported results (19), and indicate that the knockdown of Beclin 1 expression did not significantly affect hepatoma cell proliferation and spontaneous apoptosis. However, our data were in disagreement with the finding that the partial downregulation of Beclin 1 expression augmented the apoptosis of HepG2 cells in vitro (19). This difference may be due to the use of different hepatoma cell lines or different experimental conditions.…”
Section: Discussionsupporting
confidence: 94%
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“…A number of emerging pieces of evidence point to a prosurvival role for autophagy. Inactivation of the essential autophagy gene BECN1 results in apoptotic cell death in different models (8,11,55). Autophagy has been shown to represent a temporary survival pathway that counteracts metabolic stress in tumors with defective apoptosis, and it is required for the maintenance of energy homeostasis in healthy cells during postnatal starvation (29).…”
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confidence: 99%