2019
DOI: 10.1155/2019/6747190
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Partial Characterization of Novel Bacteriocin SF1 Produced by Shigella flexneri and Their Lethal Activity on Members of Gut Microbiota

Abstract: A strain of Shigella flexneri producing bacteriocin was isolated from a patient with diarrhea. The main objective of this study was to isolate and partially characterize the bacteriocin. The producing microorganism was identified using biochemical, serological, and molecular methods. The lethal activity of the S. flexneri strain was studied using the drop method. This bacterial strain showed activity against different strains of E. coli and B. fragilis. Using immunological techniques, it was determined that S.… Show more

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Cited by 4 publications
(2 citation statements)
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“…Considering their remarkably low infectious doses, S. flexneri and S. sonnei are presumed to have developed specific defensive mechanisms to survive in the intestinal environment and triumph in the competition against the local microbiota while being definitely outnumbered [ 49 ]. It is probable that the production of bacteriocins, such as SF1 and colicin, by certain strains of S. flexneri and S. sonnei , respectively, may help in killing members of the gut microbiota (i.e., E. coli , Bacteroides fragilis ), thus ensuring a selective advantage for the pathogen during the colonization and invasion processes [ 146 , 147 ]. On the other hand, bacteriocins produced by intestinal commensals were demonstrated to be equally effective in protecting against S. flexneri colonization.…”
Section: Intestinal Pathogens and Gut Microbiotamentioning
confidence: 99%
“…Considering their remarkably low infectious doses, S. flexneri and S. sonnei are presumed to have developed specific defensive mechanisms to survive in the intestinal environment and triumph in the competition against the local microbiota while being definitely outnumbered [ 49 ]. It is probable that the production of bacteriocins, such as SF1 and colicin, by certain strains of S. flexneri and S. sonnei , respectively, may help in killing members of the gut microbiota (i.e., E. coli , Bacteroides fragilis ), thus ensuring a selective advantage for the pathogen during the colonization and invasion processes [ 146 , 147 ]. On the other hand, bacteriocins produced by intestinal commensals were demonstrated to be equally effective in protecting against S. flexneri colonization.…”
Section: Intestinal Pathogens and Gut Microbiotamentioning
confidence: 99%
“…The proteases used in the evaluations are commonly employed in the characterisation of these peptides because they have a broad specificity of action. Some bacteriocins have complete inhibition of biological activity after treatment with such enzymes (Dey, Rai, Das, Mandal, & Mandal, 2019;Padilla, Carrasco-Sánchez, Padilla, & Lobos, 2019;Zhu, Zhao, Sun, & Gu, 2014). However, it has been shown that bacteriocins have different levels of sensitivity to enzymatic treatments because of their composition and structure (Ge, Sun, Xin, Wang, & Ping, 2016).…”
Section: Discussionmentioning
confidence: 99%