Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors

Amen, Yhiya; Zhu, Qing; Tran, Hai Bang; Afifi, Mohamed; Halim, Ahmed F.; Ashour, Ahmed; Shimizu, Kuniyoshi

doi:10.1007/s11418-016-1069-y

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…Triterpenes, polysaccharide peptides, polysaccharides, ganoderic acids, and ribonucleases isolated from the fruiting bodies and fermentation of Ganoderma spp. exhibit antioxidant, antiallergic, antiinflammatory, antifungal, antitumor, immunostimulatory, and mitogenic activities 4 – 12 . As a species of G. lucidum complex, G. oregonense was first discovered in North America 1 .…”

Section: Introductionmentioning

confidence: 99%

Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress

Chen

Wang

et al. 2017

Sci Rep

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Ganoderma is well known for its use in traditional Chinese medicine and is widely cultivated in China, Korea, and Japan. Increased temperatures associated with global warming are negatively influencing the growth and development of Ganoderma. Nitric oxide is reported to play an important role in alleviating fungal heat stress (HS). However, the transcriptional profiling of Ganoderma oregonense in response to HS, as well as the transcriptional response regulated by NO to cope with HS has not been reported. We used RNA-Seq technology to generate large-scale transcriptome data from G. oregonense mycelia subjected to HS (32 °C) and exposed to concentrations of exogenous NO. The results showed that heat shock proteins (HSPs), “probable stress-induced proteins”, and unigenes involved in “D-amino-acid oxidase activity” and “oxidoreductase activity” were significantly up-regulated in G. oregonense subjected to HS (P < 0.05). The significantly up-regulated HSPs, “monooxygenases”, “alcohol dehydrogenase”, and “FAD/NAD(P)-binding domain-containing proteins” (P < 0.05) regulated by exogenous NO may play important roles in the enhanced HS tolerance of G. oregonense. These results provide insights into the transcriptional response of G. oregonense to HS and the mechanism by which NO enhances the HS tolerance of fungi at the gene expression level.

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Section: Introductionmentioning

confidence: 99%

Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress

Chen

Wang

et al. 2017

Sci Rep

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“…15,34 To date, numerous ROCK inhibitors have been developed with most of them functioning as ATP competitive kinase inhibitors. 35 Based on the reported X-ray crystal structure and computer-predicted substrate-enzyme interaction model, 15,36,37 most reported synthetic ROCK inhibitors consist of 3 moieties (Figure 1). Part A, which is the hinge-binding moiety, is the nitrogen-containing aromatic ring, such as pyridine, pyrazole, or azaindole.…”

Section: Synthetic Rock Inhibitorsmentioning

confidence: 99%

Recent advances in the development of Rho kinase inhibitors (2015–2021)

Yao

2023

Medicinal Research Reviews

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Rho‐associated coiled‐coil kinases (ROCKs) are key downstream effectors of small GTPases. ROCK plays a central role in diverse cellular events with accumulating evidence supporting the concept that ROCK is important in tumor development and progression. Numerous ROCK inhibitors have been investigated for their therapeutic potential in the treatment of cancers. In this article, we review recent research progress on ROCK inhibitors, especially those with potential for the treatment of cancers, reported in the literature from 2015 to 2021. Most ROCK inhibitors show potent in vitro and in vivo antitumor activities and have potential in the treatment of cancers.

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“…Amen et al studied the ethanol extract of Ganodermal lingzhi for the ability to inhibit Rho-kinases ROCK-I and ROCK-II and identified 35 compounds [80]. Lanostane triterpenoids were found to have the most potent activities.…”

Section: Uveal Melanomamentioning

confidence: 99%

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Zhang

Gallo

Tao

et al. 2018

Pharmacological Research

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Carcinogenesis has a multifactorial etiology, and the underlying molecular pathogenesis is still not entirely understood, especially for eye cancers. Primary malignant intraocular neoplasms are relatively rare, but delayed detection and inappropriate management contribute to poor outcomes. Conventional treatment, such as orbital exenteration, chemotherapy, or radiotherapy, alone results in high mortality for many of these malignancies. Recent sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve management. Transcription factors are proteins that regulate gene expression by modulating the synthesis of mRNA. Since transcription is a dominant control point in the production of many proteins, transcription factors represent key regulators for numerous cellular functions, including proliferation, differentiation, and apoptosis, making them compelling targets for drug development. Natural compounds have been studied for their potential to be potent yet safe chemotherapeutic drugs. Since the ancient times, plant-derived bioactive molecules have been used to treat dreadful diseases like cancer, and several refined pharmaceutics have been developed from these compounds. Understanding targeting mechanisms of oncogenic transcription factors by natural products can add to our oncologic management toolbox. This review summarizes the current findings of natural products in targeting specific oncogenic transcription factors in various types of eye cancer.

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Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors

Cited by 11 publications

References 29 publications

Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress

Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress

Recent advances in the development of Rho kinase inhibitors (2015–2021)

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

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