Partial deletion of the Y chromosome removes the effect of paternal genome imprinting on periovum sensitivity to hyaluronidase in mice

Styrna, Józefa

doi:10.1017/s0016672300033309

Cited by 3 publications

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“…Previous experiments carried out in our laboratory have revealed many subtle but noticeable differences in reproductive qualities of females from the congenic B10.BR and B10.BR- Y del strains of mice. [14][15][16] These differences between genetically identical females were explained by indirect influence of paternal Y chromosomes that participate in the establishment of heritable epigenetic marks in X-bearing sperm. Cumulus cells surrounding oocytes of B10.BR(Y del ) females just prior and after ovulation present more prostaglandin EP2 receptors and produce more prostaglandin E 2 than analogous cells of B10.BR females.…”

Section: Discussionmentioning

confidence: 99%

“…Experiments on XY RIII qdel male mice (with a very similar to B10.BR-Y del deletion removing 2/3 of the MSYq) proved that this phenomenon is caused not by a reduced frequency of Y-bearing sperm in ejaculate but by their poorer fertilizing ability in comparison with X-bearing counterparts. 13 Genetically identical females of the both congenic strains vary in some reproductive features as well, [14][15][16] which can be explained only by transgenerational influence of parental Y chromosomes. Epigenetic modifications of genetic material in X-bearing spermatozoa seem to be the possible mechanism of such influence.…”

Section: Introductionmentioning

confidence: 99%

“…16 It is also more resistant to enzymatic treatment as well as to sperm activity in vitro. 14,15 These features decrease fertilization efficiency of B10.BR(Y del ) oocytes, but only in the case of mating with B10.BR-Y del males, producing poor-quality sperm. 15 Additionally, females sired by males with the deleted Y chromosome exhibit increased prostaglandin E 2 -EP2 receptor signaling in their periovulatory processes.…”

Section: Introductionmentioning

confidence: 99%

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Increased Progesterone Production in Cumulus—Oocyte Complexes of Female Mice Sired by Males With the Y-Chromosome Long Arm Deletion and its Potential Influence on Fertilization Efficiency

et al. 2015

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It was revealed previously that B10.BR(Y del ) females sired by males with the Y-chromosome long arm deletion differ from genetically identical B10.BR females sired by males with the intact Y chromosome. This is interpreted as a result of different epigenetic information which females of both groups inherit from their fathers. In the following study, we show that cumulus-oocyte complexes ovulated by B10.BR(Y del ) females synthesize increased amounts of progesterone, which is important sperm stimulator. Because their extracellular matrix is excessively firm, the increased progesterone secretion belongs presumably to factors that compensate this feature enabling unchanged fertilization ratios. Described compensatory mechanism can act only on sperm of high quality, presenting proper receptors. Indeed, low proportion of sperm of Y del males that poorly fertilize B10.BR(Y del ) oocytes demonstrates positive staining of membrane progesterone receptors. This proportion is significantly higher for sperm of control males that fertilize B10.BR(Y del ) and B10.BR oocytes with the same efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased Progesterone Production in Cumulus—Oocyte Complexes of Female Mice Sired by Males With the Y-Chromosome Long Arm Deletion and its Potential Influence on Fertilization Efficiency

et al. 2015

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Increased prostaglandin E2–EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletion

Kotarska

Lenartowicz

Przybyło

et al. 2013

Reprod. Fertil. Dev.

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Cumuli oophori surrounding ovulated oocytes of B10.BR(Y(del)) females (sired by males with the Y-chromosome long-arm deletion) are more resistant to hyaluronidase digestion than cumuli oophori around eggs of genetically identical females but sired by males with the intact Y chromosome (B10.BR). This has been interpreted as a result of differences in paternal genome imprinting, which females of both groups inherit from their fathers. The following study shows that it is not hyaluronan, but rather excessive protein concentration, that makes the cumulus extracellular matrix of B10.BR(Y(del)) oocytes more resistant to enzymatic treatment. It was revealed, additionally, that cumulus cells around ovulating oocytes of B10.BR(Y(del)) females display higher surface accumulation of prostaglandin EP2 subtype receptors and higher expression of the Ptgs2 gene (encoding a rate-limiting enzyme of prostaglandin E₂ synthesis) in relation to the cells of control B10.BR females. The expression levels of the prostaglandin-dependent Tnfaip6 and Ccl2 genes were also altered in B10.BR(Y(del)) cumulus cells in a manner indicating increased prostaglandin signalling. The study provides further evidence for the divergence in reproductive phenotypes between B10.BR and B10.BR(Y(del)) female mice. It supports the hypothesis that genes of the Y-chromosome long arm may be involved in establishment of epigenetic marks in X-bearing spermatozoa.

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Can the partial deletion in the Y chromosome of male mice affect the reproductive efficiency of their daughters?

Kotarska

Styrna

2011

Systems Biology in Reproductive Medicine

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It has been previously shown that cumuli oophori around ovulated oocytes of B10.BR-Y(del) female mice (sired by males with the deleted Y chromosome) are more resistant to enzymatic treatment than cumuli oophori around eggs of control B10.BR females (having fathers with the intact Y chromosome). This can imply that some genes which influence the establishment of the imprinting pattern in male gametes are located in the region covered by the deletion. We hypothesize that the Y-dependent imprinting pattern, inherited by female offspring, affects stability of periovum layers within them. In the present study, cumulus-oocyte complexes ovulated by females from consomic strains: DBA, DBA-Y(BR), DBA-Y(del), and CBA, CBA-Y(BR), CBA-Y(del) were tested for their susceptibility to hyaluronidase digestion. The mean times for dispersal of cumulus cells surrounding oocytes of females from the backcross lines were convergent with the times typical for oocytes from strains being the donors of the Y chromosome (B10.BR or B10.BR-Y(del)) and differed clearly from pure DBA and CBA strains. It confirmed previous findings that Y chromosomes of fathers influence the properties of cumulus-oocyte complexes ovulated by their daughters. This influence is definitely stronger than the influence of the genetic background. Additionally, it was demonstrated that the cumuli oophori surrounding oocytes of B10.BR-Y(del) females exhibit increased resistance to penetration by spermatozoa in vitro, in comparison to the control B10.BR strain. This regularity was reflected in the decreased proportion of fertilized ova recovered from oviducts of B10.BR-Y(del) females mated with B10.BR-Y(del) males and in the lower litter sizes recorded for these pairs. The excessive stability of cumuli oophori typical for oocytes of females having Y(del) fathers may negatively affect their fertility, if they have partners producing poor quality sperm.

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Partial deletion of the Y chromosome removes the effect of paternal genome imprinting on periovum sensitivity to hyaluronidase in mice

Cited by 3 publications

References 7 publications

Increased Progesterone Production in Cumulus—Oocyte Complexes of Female Mice Sired by Males With the Y-Chromosome Long Arm Deletion and its Potential Influence on Fertilization Efficiency

Increased Progesterone Production in Cumulus—Oocyte Complexes of Female Mice Sired by Males With the Y-Chromosome Long Arm Deletion and its Potential Influence on Fertilization Efficiency

Increased prostaglandin E2–EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletion

Can the partial deletion in the Y chromosome of male mice affect the reproductive efficiency of their daughters?

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