Partial Epilepsy with Seizures Appearing in the First Three Years of Life

Oller-Daurella, L; Oiler, Luis F. V.

doi:10.1111/j.1528-1157.1989.tb05345.x

Cited by 16 publications

(6 citation statements)

References 2 publications

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“…Simple motor seizures and hypomotor seizures accounted for all seizure types observed in patients younger than three years of age. This has already been observed in previous studies (Duchowny, ; Yamamoto et al , ; Oller‐Daurella and Oller, ; Brockhaus and Elger, ; Hamer et al ., ; Fogarasi et al , ; Ray and Kotagal, ). Most of the simple motor seizures in this age group (one month to three years old) were generalized (generalized epileptic spasms and generalized tonic, generalized myoclonic, and generalized clonic seizures).…”

Section: Discussionsupporting

confidence: 85%

“…Seizure semiology in different age groups Yamamoto et al, 1987;Oller-Daurella and Oller, 1989;Brockhaus and Elger, 1995;Hamer et al, 1999;Fogarasi et al, 2002;Ray and Kotagal, 2005). Most of the simple motor seizures in this age group (one month to three years old) were generalized (generalized epileptic spasms and generalized tonic, generalized myoclonic, and generalized clonic seizures).…”

Section: Discussionmentioning

confidence: 99%

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Epileptic seizure semiology in different age groups

Vaca

Mayor

Losarcos

et al. 2018

Epileptic Disorders

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Aims. Seizure semiology provides information about the eloquent cortex involved during a seizure and helps to generate a hypothesis regarding the localization of the epileptogenic zone (EZ), a prerequisite for surgical management of epilepsy. We aimed to study the seizure semiology among all different age groups to better characterize semiological changes that occur with age. Methods. We performed a retrospective review of video‐EEG data in paediatric and adult patients admitted to the Epilepsy Monitoring Unit over a three‐year period. Authors independently reviewed and classified the seizure semiology while blinded to clinical, EEG, and neuroimaging data. A total of 270 patients were included in the study. Results. The most frequent EZ in patients who were one month to three years old was undetermined. Focal epilepsy became more frequent in patients older than 10 years. Among patients with focal epilepsy, a posterior quadrant EZ was most frequent in children younger than three years old, a temporal EZ between three and six years old, and a frontal EZ between six and 10 years old. The temporal lobe was the most frequent location for focal EZ in patients older than 18 years. Auras, automotor seizures, and generalized tonic‐clonic seizures were extremely infrequent in patients younger than 10 years old. The youngest patient with auras was 5.7 years old. The youngest patient with automotor seizures was 3.7 years old. We identified only three patients with generalized tonic‐clonic seizures who were younger than 10 years (aged six months, 6.6 years, and nine years, respectively). Patients younger than three years exhibited mostly generalized simple motor seizures and hypomotor seizures. Generalized epileptic spasms, generalized tonic seizures, and generalized clonic seizures were infrequent in patients older than 10 years. Conclusion. Seizure semiology and electroencephalographic changes most likely reflect the maturation of cortical functions.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Epileptic seizure semiology in different age groups

Vaca

Mayor

Losarcos

et al. 2018

Epileptic Disorders

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“…Partial epilepsy is considered rare in the first 3 years of life (Oller-Daurella and Oller, 1989), but this may be because initial partial seizure manifestations except for localized motor phenomena are easily missed. All of our study infants had apparent GTCs which ultimately were shown to be partial seizures evolving to secondarily generalized seizures.…”

Section: Discussionmentioning

confidence: 99%

Benign Partial Epilepsy with Secondarily Generalized Seizures in Infancy

1993

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Seven infants with benign idiopathic partial epilepsy presented with apparently generalized tonic-clonic seizures (GTCs) which proved to be partial seizures evolving to secondarily generalized seizures. All were easily controlled with phenobarbital (PB) or carbamazepine (CBZ), and remained seizure-free > 3 years even after discontinuation of medication, and had a normal developmental outcome. The initial seizure manifestation consisting of motion arrest, staring or blank eyes, or crying associated with focal paroxysmal discharges was followed by GTCs in accordance with generalization of paroxysmal discharges. Four infants had a family history of benign type of childhood convulsions. The term "benign partial epilepsy in infancy" is proposed to combine this syndrome with the previously described benign infantile epilepsy with complex partial seizures.

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“…Once such gestures develop later in life, they can be incorporated into complex automatisms [9, 22]. Given the lack of well-developed verbal communication skills in children aged 0–3 years, it is usually impossible for clinicians to properly assess for auras at seizure onset [9, 12, 26]. Rather, the earliest signs of such seizures in infants and toddlers may be behavioral arrest, staring, and lip cyanosis [25].…”

Section: Semiology Of Temporal Lobe Seizures In Childrenmentioning

confidence: 99%

Temporal Lobe Epilepsy in Children

Nickels

Wong‐Kisiel

Moseley

et al. 2012

Epilepsy Research and Treatment

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The temporal lobe is a common focus for epilepsy. Temporal lobe epilepsy in infants and children differs from the relatively homogeneous syndrome seen in adults in several important clinical and pathological ways. Seizure semiology varies by age, and the ictal EEG pattern may be less clear cut than what is seen in adults. Additionally, the occurrence of intractable seizures in the developing brain may impact neurocognitive function remote from the temporal area. While many children will respond favorably to medical therapy, those with focal imaging abnormalities including cortical dysplasia, hippocampal sclerosis, or low-grade tumors are likely to be intractable. Expedient workup and surgical intervention in these medically intractable cases are needed to maximize long-term developmental outcome.

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Partial Epilepsy with Seizures Appearing in the First Three Years of Life

Cited by 16 publications

References 2 publications

Epileptic seizure semiology in different age groups

Epileptic seizure semiology in different age groups

Benign Partial Epilepsy with Secondarily Generalized Seizures in Infancy

Temporal Lobe Epilepsy in Children

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