Partial hydatidiform mole and hypertension associated with a live fetus--variable presentation in two cases

Nwosu, E. C.; Ferriman, E; McCormack, M; Williams, Jennet; Gosden, Christine

doi:10.1093/oxfordjournals.humrep.a136320

Cited by 17 publications

(9 citation statements)

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“…In our patient, placentomegaly and high levels of β-hCG accompanied the development of preeclampsia. This is consistent with the reported series of Rijhsinghani et al [3] and two other case reports of triploid twin pregnancies complicated by preeclampsia [4,6]. …”

Section: Discussionsupporting

confidence: 93%

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Transient early preeclampsia in twin pregnancy with a triploid fetus: a case report

2009

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IntroductionTriploid pregnancies have an increased risk of early preeclampsia. Twin pregnancies consisting of one healthy fetus and one complete or partial molar, with or without a triploid fetus, are rare and management is complex.Case presentationA 33-year-old Caucasian woman presented with a dichorionic diamniotic twin pregnancy. One fetus showed early growth restriction resulting in fetal death at 20 weeks. The placenta was enlarged with some cysts. Chorionic villus biopsy confirmed triploidy. At 21 weeks, the patient developed preeclampsia with a blood pressure of 154/98 mmHg and proteinuria (24 hour protein excretion of 2.5 g/L), for which she was hospitalized. Without pharmacological interventions, the blood pressure normalized and proteinuria disappeared. At 35 weeks, she again developed preeclampsia. A cesarean section was performed at 38 weeks and a healthy child was born.ConclusionsSurvival of the healthy fetus is possible in a twin pregnancy with a triploid fetus complicated by early preeclampsia. The pregnancy should not be terminated if the triploid twin has died and as long as conservative management is safe.

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Section: Discussionsupporting

confidence: 93%

“…In three cases [4]-[6] of five concerning a triploid fetus and a healthy co-twin, a therapeutic abortion was performed, two of which were for severe preeclampsia. There are only two cases reported with survival of the healthy co-twin, both after selective abortion of the triploid fetus.…”

Section: Introductionmentioning

confidence: 99%

Transient early preeclampsia in twin pregnancy with a triploid fetus: a case report

2009

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“…From this clinical perspective there are two different type of gross pathology that can affect the placenta, focal degeneration and diffuse partial degeneration. (12,15,16,17) Molar pregnancy with co-existing normal live foetus has been divided into three types. The first and most common is twin pregnancy with one normal fetus having a normal placenta and another complete mole, second type is a twin pregnancy with normal fetus and the placenta and another partial mole.The third and most uncommon occurrence is a singleton normal fetus with partial molar placenta 13 similar to our case.…”

Section: Discussionmentioning

confidence: 99%

Partial Hydatidiform Mole with Alive Term IUGR Foetus

Ara¹,

Begum²,

Kasem³

et al. 2017

J. Bangladesh Coll. Phys.

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Gestational Trophoblastic diseases consist of a broadspectrum of conditions ranging from an uncomplicated partial hydatidiform molar pregnancy to stage -IV choriocarcinoma with cerebral metastasis. Incidence of hydatidiform mole with a co-existing live fetus varies between 0.005 to 0.01 % of all pregnancies. We report a case of partial molar pregnancy with alive term IUGR (intrauterine growth retardation) foetus. Diagnosis was made by sonographic findings of molar changes at her 28 weeks of gestation.Anomaly scan showed no fetal abnormality. At 40 weeks of pregnancy patient went to spontaneous labour and delivered a severely IUGR baby weighing 1.5 kg and it was morphologically normal. There was a single placenta; one third of it was replaced by molar tissue. As the singletone alive pregnancy with partial molar changes is extremely rare occurrence we reported the case here.

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“…Nwosu et al reported that no reports demonstrate that if pregnancy is kept to term, it will increase the incidence of invasive mole or choriocarcinoma. 15 Zahida P et al from Pakistan, reported G4 P1 + 2 lady with partial mole along with alive baby managed conservatively 18 weeks onward and delivered successfully at term. 16 Hsieh CC et al from Department of Obstetrics and Gynecology, Taiwan, Republic of China, reported delivery of a severely anemic fetus after partial molar pregnancy.…”

Section: Pregnancymentioning

confidence: 99%

Partial Mole with a Coexistent Viable Fetus—A Clinical Dilemma: A Case Report with Review of Literature

Rathod¹,

Pajai²,

Gaddikeri³

2014

Journal of South Asian Federation of Obstetrics and Gynaecology

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Gestational trophoblastic disease encompasses a diverse group of lesions. If molar changes in the placenta are known along with an alive fetus, then situation is difficult for both obstetrician and parents. On one hand, there may be a normal pregnancy whereas on the other hand the mother may be threatened by numerous complications caused by the hydatid mole, if the pregnancy is continued.We present successfully managed case of partial molar pregnancy with an alive fetus at 1st stage of preterm labor with premature rupture of membranes with anemia with a live diploid female fetus with good neonatal out come. Follow-up till 1 year showed no progression to malignant gestational trophoblastic diseases.

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Partial hydatidiform mole and hypertension associated with a live fetus--variable presentation in two cases

Cited by 17 publications

References 0 publications

Transient early preeclampsia in twin pregnancy with a triploid fetus: a case report

Transient early preeclampsia in twin pregnancy with a triploid fetus: a case report

Partial Hydatidiform Mole with Alive Term IUGR Foetus

Partial Mole with a Coexistent Viable Fetus—A Clinical Dilemma: A Case Report with Review of Literature

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