Partial Hydrolysis Products Derived from Proteins and their Significance for Protein Structure.

The Microheterogeneity of Proteins.

“…The definition of microheterogeneity given here is a generalization from the use of the term by Synge(141) and appears to be consistent with his application.…”

“…Throughout, the predominantly polypeptide chain structure of proteins will be assumed to be correct (124,141).…”

“…He also indicated the many opportunities for small differences between large particles of similar construction. Synge, too, after referring to the evidence for small differences in structure between members of families of polypeptides, suggested that similar differences would be found within the more complex proteins (141). Later refinements of experimental technique, which are indicated in several recent surveys of methods (38,94,144), have tended to confirm this prediction.…”

The Protein chemistry of enzymes

“…By 1970 the complete molecular structures of several enzymes were established and plausible reaction mechanisms could be discussed. As Synge so rightly observed in 1943 [91], advances in technique were the prerequisite for advances in our knowledge of protein chemistry. In the issue of Brighter Biochemistry dated May 1931 (the lighthearted house journal of the Department of Biochemistry in Cambridge from 1924-1931), a spoof examination paper for the undergraduates of twenty-five years later was offered by J.B.S.…”

The Early History of Chemical Reviews: “Established To Fill a Definite Want”

“…52 The international character of the contributors that had been set in the first volume continued, although somewhat abated by World War II. Even in the depths of war, papers arrived from England like R. L. M. Synge's paper written at the Wool Industries Research Association in Leeds and received at Chemical Reviews in November 1941, 53 as well as Brynmor Jones's from Sheffield University, received in July 1944; 54 others came from faraway India. 55,56 Leading-edge information technology was visible in the 1940 Chemical Reviews volume in the offer of microfilming services made by the Committee on Scientific Aids to Learning.…”