Partial least-squares method in analysis by differential pulse polarography. Simultaneous determination of amiloride and hydrochlorothiazide in pharmaceutical preparations

Martín, Miriam; Hernández, Oscar; Jiménez, Ana I.; Arias, J. J.; Jiménez, Francisco Jiménez

doi:10.1016/s0003-2670(98)00732-6

Cited by 71 publications

(30 citation statements)

References 22 publications

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“…Several analytical methods have been published for the determination of Hydrchlorothiazide in tablet susingflowinjection 6 , spectrophotometric [7][8][9] , densitometric 10 , HPLC [7][8][9][10][11][12][13] , electrophoretic [14][15] andpolarographic 16 methods. The simultaneous determination of EPR and HCTZ was studied by HPTLC 17 , HPLC and derivative spectrophotmetry 18 .…”

Section: Figure 2 Chemical Structures Of Hydrchlorothiazide (Hctz)mentioning

confidence: 99%

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

2014

Chem Sci Trans

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A validated stability-indicating high-performance liquid chromatographic method has been developed for the simultaneous determination of Eprosartan and hydrochlorothiazide in tablet dosage forms. Chromatographic separation was performed on HPLC system of waters Model 2997 using X Bridge Shield RP18 (150 x 3.0 mm i.d., 3.5 µm particle size) column with a mixture of 0.1% formic acid and acetonitrile as mobile phase with a flow rate of 0.8 mL/min (gradient mode) with UV detection at 235 nm. The combinationof drugs was subjected to stress conditions such as acidic, alkaline, oxidation photolytic and thermal degradations and the method was validated as per ICH guidelines.

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Section: Figure 2 Chemical Structures Of Hydrchlorothiazide (Hctz)mentioning

confidence: 99%

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

2014

Chem Sci Trans

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“…Amiloride in plasma has a half life of 6 to 10 h and about 50% of an oral dose is excreted in the unchanged form in urine. 3 Amiloride has been individually determined in pharmaceutical preparations and biological fluids like urine and plasma using several methods including spectrophotometry, [4][5][6][7] high performance liquid chromatography, [8][9][10] fluorimetry, [11][12][13] capillary isotachophoresis, 14 chemiluminescence oxidation, 15 differential-pulse polarography, 16 differential-pulse stripping voltammetry, 17 and potentiometry. 18 Potentiometric detection based on ion-selective electrodes (ISEs) offers several advantages such as ease of preparation and procedures, simple instrumentation, relatively fast response, wide dynamic range, reasonable selectivity, and low cost.…”

Section: Introductionmentioning

confidence: 99%

A DNA-based coated wire membrane sensor for selective determination of amiloride in pharmaceutical compounds, plasma and urine

Allafchian¹,

Ensafi²

2010

J. Braz. Chem. Soc.

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A construção e características do desempenho de um eletrodo de membrana polimérica baseadas na formação de par iônico para quantificação de amilorida em ds-DNA-amilorida de esperma de salmão são descritas. O filme de ds-DNA-amilorida em esperma de salmão pode ser facilmente preparado como uma camada de cobertura em um eletrodo de fio de platina. Este eletrodo apresenta uma boa resposta potenciométrica para amilorida. As características do desempenho são influenciadas pela composição da membrana e a resposta potenciométrica do eletrodo pode melhorar substancialmente. A melhor performance foi obtida com o eletrodo apresentando uma composição da membrana (m/m) de 6,4% de ds-DNA-amilorida como par iônico, 62,9% de cloreto de polivinila como matriz e 30,7% de nitrofenil octileter (NPOE) como um íon exclusor. O eletrodo proposto exibe resposta Nernstiniana no intervalo de concentração de 1,6 × 10 -6 a 1,0 × 10 -2 mol L -1 de amilorida com um limite de detecção de 1,5 × 10 -6 mol L -1 de amilorida e um rápido tempo de resposta, de 5 s. Coeficientes de seletividade para amilorida relativa aos números de substâncias interferentes foram investigados. O sensor foi altamente seletivo para amilorida, em um grande número de compostos. O uso analítico do eletrodo proposto foi avaliado pela aplicação na determinação de amilorida em amostras reais.Herein, the construction and performance characteristic of a polymeric membrane electrode based on ion-pair formation of salmon sperm ds-DNA-amiloride for quantification of amiloride is described. Salmon sperm ds-DNA-amiloride layer can be prepared easily as a coating layer on a Pt-wire electrode. This electrode has a good potentiometric response to amiloride. The influences of the membrane compositions on the potentiometric response of the electrode have been found to substantially improve the performance characteristics. The best performance was obtained with the electrode having a membrane composition (m/m) of ds-DNA-amiloride as an ion pair (6.4%), polyvinyl chloride (PVC) matrix (62.9%), and 2-nitrophenyl octylether (NPOE) as an ion excluder (30.7%). The proposed electrode exhibits Nernstian response in the concentration range of 1.6 × 10 -6 to 1.0 × 10 -2 mol L -1 amiloride with a detection limit of 1.5 × 10 -6 mol L -1 amiloride, performs satisfactorily with a fast response time of 5 s. Selectivity coefficients for amiloride relative to a numbers of potential interfering substances were investigated. The sensor was highly selective for amiloride over a large number of compounds. The analytical usefulness of the proposed electrode has been evaluated by its application in the determination of amiloride in real samples.

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“…17,18 Many of which are not sufficiently sensitive [10][11][12][13][14]17,18 and/or are time consuming Vol. 20, No.…”

Section: Introductionmentioning

confidence: 99%

Ferrocenedicarboxylic acid modified carbon paste electrode: a sensor for electrocatalytic determination of hydrochlorothiazide

Karimi-Maleh¹,

Ensafi²,

Ensafi³

2009

J. Braz. Chem. Soc.

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A oxidação eletrolítica de hidroclorotiazida foi estudada usando-se eletrodo de pasta de carbono modificado com ácido ferrocenodicarboxílico. Voltametria cíclica e cronoamperometria foram usadas para investigar a possibilidade de aplicação do ácido ferrocenodicarboxílico como mediador na oxidação eletrocatalítica de hidroclorotiazida em solução aquosa. A oxidação de hidroclorotiazida ocorre em um potencial, aproximadamente, 300 mV menos positivo do que com o eletrodo de pasta de carbono não modificado, em pH 9,0. A constante de velocidade da reação catalítica, k h , foi calculada (3,38 × 10 2 cm 3 mol -1 s -1) usando-se cronoamperometria. Em condições ótimas, a corrente de pico da oxidação eletrocatalítica da hidroclorotiazida mostrou dois intervalos dinâmicos lineares com limite de detecção de 0,037 μmol L -1 de hidroclorotiazida. Os intervalos de calibração lineares ocorreram entre 0,08-5,8 μmol L -1 e 5,8-500,0 μmol L -1 de hidroclorotiazida, usando-se voltametria de onda quadrada. Finalmente, o método proposto foi também examinado quanto à seletividade, simplicidade e precisão na determinação de hidroclorotiazida em amostras reais como droga e urina.The electrocatalytic oxidation of hydrochlorothiazide has been studied by ferrocenedicarboxylic acid modified carbon paste electrode. Cyclic voltammetry and chronoamperometry were used to investigate the suitability of ferrocenedicarboxylic acid as a mediator for the electrocatalytic oxidation of hydrochlorothiazide in aqueous solution. The oxidation of hydrochlorothiazide occurs at a potential about 300 mV less positive than with the unmodified carbon paste electrode at pH 9.0. The catalytic reaction rate constant, k h was calculated (3.38 × 10 2 cm 3 mol -1 s -1 ) using chronoamperometry. Under the optimized conditions, the electrocatalytic oxidation peak current of hydrochlorothiazide showed two linear dynamic ranges with a detection limit of 0.037 μmol L -1 hydrochlorothiazide. The linear calibration ranges were between 0.08-5.8 μmol L -1 and 5.8-500.0 μmol L -1 hydrochlorothiazide using square wave voltammetric method. Finally, the proposed method was also examined as a selective, simple and precise electrochemical sensor for the determination of hydrochlorothiazide in real samples such as drug and urine.Keywords: ferrocenedicarboxylic acid, hydrochlorothiazide, electrocatalysis, square wave voltammetry IntroductionHydrochlorothiazide (HCTZ) (6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide) has gained attention because it is a benzothiazide diuretic that acts directly on the kidney by increasing the excretion of sodium chloride and water and, to a lesser extent, that of potassium ions. HCTZ is an antihypertensive substance and improves the action of other hypotensive substances, allowing a decrease in the dose of those below the level where these substances present secondary effects. Novello and Sprague observed the diuretic effect of thiazides with chlorothiazide in 1957.1 HCTZ is well absorbed, is shortly bound to plasma proteins, and ma...

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Partial least-squares method in analysis by differential pulse polarography. Simultaneous determination of amiloride and hydrochlorothiazide in pharmaceutical preparations

Cited by 71 publications

References 22 publications

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

A DNA-based coated wire membrane sensor for selective determination of amiloride in pharmaceutical compounds, plasma and urine

Ferrocenedicarboxylic acid modified carbon paste electrode: a sensor for electrocatalytic determination of hydrochlorothiazide

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