Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome

Galvin, I.; Steel, Andrew; Pinto, Ruxandra; Ferguson, Niall D.; Davies, Mark W

doi:10.1002/14651858.cd003707.pub3

Cited by 25 publications

(15 citation statements)

References 45 publications

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“…) or partial liquid ventilation with perfluorocarbons to improve lung compliance, provide liquid positive PEEP, and improve ventilation‐perfusion matching (Galvin et al. ). Current recommendations from the National Institute of Health ARDS network for mechanical ventilation are a low

{\dot{V}}_{T}

(6 mL kg −1 ), initial use of PEEP 8–12 cmH 2 O, and using <100% oxygen.…”

Section: The Immune Response To Mechanical Ventilationmentioning

confidence: 99%

The immune response to anesthesia: Part 1

Anderson

Duke‐Novakovski

Singh

2014

Veterinary Anaesthesia and Analgesia

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{\dot{V}}_{T}

(6 mL kg −1 ), initial use of PEEP 8–12 cmH 2 O, and using <100% oxygen.…”

Section: The Immune Response To Mechanical Ventilationmentioning

confidence: 99%

The immune response to anesthesia: Part 1

Anderson

Duke‐Novakovski

Singh

2014

Veterinary Anaesthesia and Analgesia

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“…Although lung protective ventilatory strategies have been widely applied, the mortality caused by ALI/ARDS is still high (Rubenfeld et al 2005;Galvin et al 2013). Therefore, a novel effective therapy is urgently required.…”

Section: Introductionmentioning

confidence: 99%

Standardized myrtol attenuates lipopolysaccharide induced acute lung injury in mice

Wan

et al. 2016

Pharmaceutical Biology

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Context: Standardized myrtol, an essential oil containing primarily cineole, limonene and a-pinene, has been used for treating nasosinusitis, bronchitis and chronic obstructive pulmonary disease (COPD). Objective: To investigate the effects of standardized myrtol in a model of acute lung injury (ALI) induced by lipopolysaccharides (LPS). Materials and methods: Male BALB/c mice were treated with standardized myrtol for 1.5 h prior to exposure of atomized LPS. Six hours after LPS challenge, lung injury was determined by the neutrophil recruitment, cytokine levels and total protein concentration in the bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) activity in the lung tissue. Additionally, pathological changes and NF-jB activation in the lung were examined by haematoxylin and eosin staining and western blot, respectively. Results: In LPS-challenged mice, standardized myrtol at a dose of 1200 mg/kg significantly inhibited the neutrophile counts (from 820.97 ± 142.44 to 280.42 ± 65.45, 10 3 /mL), protein concentration (from 0.331 ± 0.02 to 0.183 ± 0.01, mg/mL) and inflammatory cytokines level (TNF-a: from 6072.70 ± 748.40 to 2317.70 ± 500.14, ng/mL; IL-6: from 1184.85 ± 143.58 to 509.57 ± 133.03, ng/mL) in BALF. Standardized myrtol also attenuated LPS-induced MPO activity (from 0.82 ± 0.04 to 0.48 ± 0.06, U/g) and pathological changes (lung injury score: from 11.67 ± 0.33 to 7.83 ± 0.79) in the lung. Further study demonstrated that standardized myrtol prevented LPS-induced NF-jB activation in lung tissues. Discussion and conclusion: Together, these data suggest that standardized myrtol has the potential to protect against LPS-induced airway inflammation in a model of ALI. ARTICLE HISTORY

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“…However, a large-scale clinical trial reported a lack of benefit of PLV in adult patients with ARDS. It was even associated with increased risk of adverse events such as hypoxia, bradycardia, and respiratory acidosis (Galvin et al, 2013). These findings reduced interest in the use of PLV in ARDS patients.…”

Section: Introductionmentioning

confidence: 98%

“…TLV has also been shown to increase the mechanical recruitment of collapsed alveoli and the ventilation/ perfusion ratio by compressing blood vessels (Davies, 1999). In addition, TLV can mechanically remove debris and secretion from the airways (Galvin et al, 2013) and present surfactant-like and antiinflammatory properties (Zhu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Liquid Ventilation for the Induction of Ultrafast Hypothermia in Resuscitation Sciences: A Review

Kohlhauer

Berdeaux

Kerber

et al. 2016

Therapeutic Hypothermia and Temperature Management

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Liquid ventilation was initially proposed for lung lavage and respiratory support. More recently, it was also investigated as an experimental strategy for ultrafast cooling or organ preservation during ischemic disorders. The goal of this article is to identify and review the studies that investigated liquid ventilation in the field of resuscitation sciences. An exhaustive analysis of the literature was performed using the Medline database up to 15th September 2015. Articles were selected according to their relevance. All articles focusing on respiratory support were excluded. On the basis of 76 retrieved studies from the Medline database, 29 were included in this review. All studies were experimental reports and most of them investigated the cooling properties of liquid ventilation in animal models of experimental cardiac arrest or coronary artery occlusion in rabbits or pigs. Animal studies demonstrated a wide range of potential applications of total liquid ventilation in resuscitation sciences. This strategy is able to provide ultrafast cooling, independent of the body weight. In animal models of cardiopulmonary resuscitation, it was shown to provide potent benefits widely linked to cooling rapidity.

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Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome

Abstract: No evidence supports the use of PLV in ALI or ARDS; some evidence suggests an increased risk of adverse events associated with its use.

Cited by 25 publications

References 45 publications

The immune response to anesthesia: Part 1

The immune response to anesthesia: Part 1

Standardized myrtol attenuates lipopolysaccharide induced acute lung injury in mice

Liquid Ventilation for the Induction of Ultrafast Hypothermia in Resuscitation Sciences: A Review

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