Partial liquid ventilation improves lung function in ventilation-induced lung injury

Abstract

Disturbances in lung function and lung mechanics are present after ventilation with high peak inspiratory pressures (PIP) and low levels of positive endexpiratory pressure (PEEP). Therefore, the authors investigated whether partial liquid ventilation can re-establish lung function after ventilation-induced lung injury.Adult rats were exposed to high PIP without PEEP for 20 min. Thereafter, the animals were randomly divided into five groups. The first group was killed immediately after randomization and used as an untreated control. The second group received only sham treatment and ventilation, and three groups received treatment with perfluorocarbon (10 mL?kg -1 , 20 mL?kg -1 , and 20 ml?kg -1 plus an additional 5 mL?kg -1 after 1 h). The four groups were maintained on mechanical ventilation for a further 2-h observation period. Blood gases, lung mechanics, total protein concentration, minimal surface tension, and small/large surfactant aggregates ratio were determined.The results show that in ventilation-induced lung injury, partial liquid ventilation with different amounts of perflubron improves gas exchange and pulmonary function, when compared to a group of animals treated with standard respiratory care. These effects have been observed despite the presence of a high intra-alveolar protein concentration, especially in those groups treated with 10 and 20 mL of perflubron.The data suggest that replacement of perfluorocarbon, lost over time, is crucial to maintain the constant effects of partial liquid ventilation. Eur Respir J 2001; 18: 93-99.

A respiratory‐gated micro‐CT comparison of respiratory patterns in free‐breathing and mechanically ventilated rats

“…; Vazquez de Anda et al. ), and can propagate the pathophysiological processes of various disease models. To ensure that the imaging procedure does not interfere with the interpretation of the measured values, or impact the well‐being of an animal that is recovered for additional experimental procedures following the micro‐CT scanning session, the animal should be maintained in a respiratory state that is more natural, either through the use of free‐breathing imaging techniques or by matching the ventilator settings to more closely represent the free‐breathing state.…”

“…; Vazquez de Anda et al. ). Mechanical ventilation can also affect the measurements of lung structure and function (Dreyfuss and Saumon ), including increased lung volumes, air content, and airway diameters which may lead to erroneous conclusions about the functional state of the lung in disease models.…”

Dose Response to Aerosolized Perflubron in a Neonatal Swine Model of Lung Injury

“…In preterm infants, surfactant deficiency, often in combination with infections, leads to respiratory distress syndrome with the need for intensive respiratory support. Mechanical ventilation itself can induce pulmonary injury via shear stress forces, initiating an inflammatory reaction (2)(3)(4).…”

A Case of Drug-Induced Pneumonitis Caused by Carvedilol

“…Admittedly, no new provocation with carvedilol was attempted. Thus there is always the remote possibility of a pneumonitis resulting from a synergistic action of carvedilol with fluoxetine [23]. …”