Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation

Prasannan-Nair, Chhaya; Reynolds, Sarah; Budden, G. C.

doi:10.1080/01443610600987092

Cited by 15 publications

(13 citation statements)

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“…A partial molar pregnancy is frequently associated with vaginal bleeding and with very severe early‐onset pre‐eclampsia, partly due to elevation in circulating anti‐angiogenic factors . Consistently, more than half (11/18 cases) showed vaginal bleeding . Moreover, pre‐eclampsia occurred in seven cases, and all of the cases ended in death of the fetus or neonate.…”

Section: Discussionmentioning

confidence: 89%

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Live‐born diploid fetus complicated with partial molar pregnancy presenting with pre‐eclampsia, maternal anemia, and seemingly huge placenta: A rare case of confined placental mosaicism and literature review

Kawasaki

Kondoh

Minamiguchi

et al. 2016

J of Obstet and Gynaecol

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A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. We describe a rare case of a singleton, partial molar pregnancy with a seemingly huge placenta, which continued to delivery of a live-born diploid baby. A 27-year-old primigravida suffered from severe pre-eclampsia and progressive anemia. The uterus was enormously enlarged for the gestational age. A cesarean section was performed because of deterioration of maternal status at 25 weeks' gestation, when more than 3000 mL blood spouted concurrently with the delivery of the placenta. The histological examination showed congestion in the decidua, which indicated disturbance of maternal venous return from the intervillous space. The chromosome complement of the placenta and the neonate were 69,XXX and 46,XX, respectively. We also reviewed all published cases of a singleton, partial molar pregnancy. A literature search yielded 18 cases of a singleton, diploid fetus with partial molar pregnancy. The mean gestational age at delivery was 24.5 ± 6.2 weeks, and fetuses survived outside the uterus in only four cases (22.2%). Intriguingly, previous reports numbered 10 cases with diploid placenta as well as five cases with no karyotyping of the placenta, indicating that they may have included a complete mole in a twin pregnancy or placental mesenchymal dysplasia. In conclusion, this was the first case of placentomegaly that presented manifestations of excessive abdominal distension and maternal severe anemia, and the second case of a singleton, partial molar pregnancy confirmed by chromosome analysis resulting in a diploid living baby.

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Section: Discussionmentioning

confidence: 89%

“…To date, 18 cases of a singleton, diploid fetus with partial molar pregnancy have been reported (Table ) . The mean gestational age at diagnosis was 18.4 ± 6.4 weeks, and there were just two cases where molar pregnancy was diagnosed after the edge of viability, that is, 23 weeks gestation.…”

Section: Discussionmentioning

confidence: 99%

Live‐born diploid fetus complicated with partial molar pregnancy presenting with pre‐eclampsia, maternal anemia, and seemingly huge placenta: A rare case of confined placental mosaicism and literature review

Kawasaki

Kondoh

Minamiguchi

et al. 2016

J of Obstet and Gynaecol

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“…Even today, hydatidiform mole is still the most likely cause of very early onset of preeclampsia. Severe very-early-onset preeclampsia has been reported to be associated with various types of hydatidiform mole, such as mole with a coexistent live fetus (3,4). Therefore, hydatidiform mole may produce conditions/factors that induce preeclampsia, although few studies have addressed this point.…”

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confidence: 97%

Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole

Koga

Osuga

Tajima

et al. 2010

Fertility and Sterility

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“…Prasannan et al reported a partial molar pregnancy accompanied by preeclampsia and fetal growth retardation diagnosed during the 12th gestational week that was followed-up until the 19th gestational week. 5 The presented case was diagnosed with severe preeclampsia due to hypertension (160/100 mmHg) and proteinuria during the 20th gestational week: therefore, antihypertensive treatment was started and although eclampsia associated with a hydatidiform mole is extremely rare; magnesium sulphate was administered for convulsion prophylaxis. 6 OHSS due to elevated β-hCG rarely is observed in molar pregnancies; because the β-hCG level is higher in cases of complete molar pregnancy OHSS is generally observed in patients with complete molar pregnancy.…”

Section: Discussionmentioning

confidence: 96%

A Case of Partial Hydatidiform Mole Presenting with Ovarian Hyperstimulation and Early Preeclampsia

Melekoğlu¹,

Eraslan²,

Çelik³

2016

Turkiye Klinikleri J Case Rep

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rare maternal complication of partial molar pregnancy is ovarian hyperstimulation syndrome (OHSS). OHSS generally occurs due to ovulation induction and rarely due to increased β-human choriogonadotrophin (β-hCG) without ovulation induction. 1 After the 20th gestational week the frequency of preeclampsia as a maternal complication of partial molar pregnancy is 41.9%, whereas the incidence of OHSS in cases of partial molar pregnancy is not known. 2 To the best of our knowledge based on a search of Türkiye Citation Index, PubMed, Medline, Embase, ScienceDirect, Cochrane and Google Scholar using the search terms molar pregnancy, hydatidiform mole, partial hydatidiform mole, pre-eclampsia, proteinuria, and ovarian hyperstimulation syndrome, A AB BS S T TR RA AC CT T Missed or incomplete abortion occurs in cases of partial molar pregnancy, whereas fetal and maternal complications, including fetal anomaly, fetal anemia, and preeclampsia, generally occur during the 20th week of gestation in cases in which the fetus remains viable. To the best of our knowledge the literature does not include any reports of partial molar pregnancy complicated by both preeclampsia and ovarian hyperstimulation. As such, this case presentation aimed to describe a patient with partial molar pregnancy with early preeclampsia and ovarian hyperstimulation, as complications, and a live fetus that was diagnosed during the 20th gestational week.

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Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation

Cited by 15 publications

References 1 publication

Live‐born diploid fetus complicated with partial molar pregnancy presenting with pre‐eclampsia, maternal anemia, and seemingly huge placenta: A rare case of confined placental mosaicism and literature review

Live‐born diploid fetus complicated with partial molar pregnancy presenting with pre‐eclampsia, maternal anemia, and seemingly huge placenta: A rare case of confined placental mosaicism and literature review

Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole

A Case of Partial Hydatidiform Mole Presenting with Ovarian Hyperstimulation and Early Preeclampsia

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