Partial mole, triploidy and proteinuric hypertension: two case reports

Rahimpanah, Farhad; Smoleniec, J. S.

doi:10.1111/j.1479-828x.2000.tb01152.x

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…These cases are termed as atypical preeclampsia [6]. Development of preeclampsia before 20 weeks of gestation usually accompanies partial molar pregnancy with triploidy or antiphospholipid syndrome [6][7][8][9]. Preeclampsia not associated with these disorders before 20 weeks of gestation is considered to be rare.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

et al. 2014

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The occurrence of preeclampsia before 20 weeks of gestation is rare and usually associated with trophoblastic diseases or antiphospholipid syndrome. Here, we report a case of preeclampsia before 20 weeks of gestation in the absence of the aforementioned disorders. A healthy 30-year-old nulliparous woman presented with new onset of hypertension and proteinuria at 18 weeks of gestation. Fetal ultrasound did not reveal any abnormalities. Empirical steroid treatment was initiated based on a tentative diagnosis of underlying renal disease. The clinical course of the disease was progressive despite steroid treatment and the fetus died in utero 8 days after the initiation of treatment. Following delivery, a renal biopsy was performed and provided a diagnosis of preeclampsia. All symptoms resolved postpartum. This report demonstrates that preeclampsia may occur before 20 weeks of gestation and should always be considered in the differential diagnosis of pregnant women with new onset of hypertension with proteinuria. Previous published cases are summarized briefly.

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Section: Discussionmentioning

confidence: 99%

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

et al. 2014

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“…Severe preeclampsia is extremely uncommon prior to 24 weeks gestation. [2][3][4][5][6] The occurrence of HELLP syndrome prior to 20 weeks gestation has been reported only twice previously. 2,3 In the case reported by Stefos et al, 2 diagnosis of a partial hydatidiform mole was suspected at 13.5 weeks gestation due to the sonographic appearance of the placenta and the maternal serum bhCG level of 200,000 mU/mL.…”

Section: Discussionmentioning

confidence: 99%

Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation

et al. 2006

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Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 x 10 (9) cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole.

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“…A literature search revealed only five published case reports of pre‐eclampsia before 20 weeks of gestation 1–5 . Of the five, four cases were associated with partial mole and triploidy where it has been postulated that the increase in paternal genetic material associated with the triploid diandric placenta may support the role of immunologic factors in the development of pre‐eclampsia.…”

Section: Discussionmentioning

confidence: 99%

‘Pure’ pre‐eclampsia before 20 weeks of gestation: a unique entity

Hazra

Waugh

Bosio

2003

BJOG

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Partial mole, triploidy and proteinuric hypertension: two case reports

Abstract: We present two cases of proteinuric hypertension in the early second trimester of pregnancy, associated with partial mole and triploidy karyotyping. This demonstrates the complementary nature of ultrasound in the diagnosis and management of this rare association.

Cited by 20 publications

References 15 publications

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation

‘Pure’ pre‐eclampsia before 20 weeks of gestation: a unique entity

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