Partial protection against 2009 pandemic influenza A (H1N1) of seasonal influenza vaccination and related regional factors: Updated systematic review and meta-analyses

Li, Zhiyuan; Chen, Jinyan; Zhang, Yanling; Fu, Weiming

doi:10.4161/21645515.2014.985495

Cited by 1 publication

(3 citation statements)

References 55 publications

(92 reference statements)

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“…Li et al . [37] report a non-significant risk increase across four randomized control trials (RR: 1.13; 95% CI 0.56–2.29), though we argue that these findings should be interpreted with caution, due to small sample size (n = 1,515). They also report a non-significant protective effect across 16 case-control studies (n = 40,868, OR: 0.80; 95% CI 0.61–1.05).…”

Section: Resultsmentioning

confidence: 58%

“…Eight [26–33] review the effectiveness of pandemic influenza vaccine in preventing influenza and influenza-like illness (ILI); three [34–36] examine the impact of antivirals; two [32, 37] review the effectiveness of seasonal influenza vaccines in preventing pandemic influenza infection; two evaluate the impact of personal protective measures (hand-washing, mask use) [38, 39]; one [40] analyzes the impact of school closure; and another [41] reviews the efficacy of traditional Chinese medicine (TCM). One review [42] evaluates the economic viability of a wide range of pharmaceutical and non-pharmaceutical measures, concluding that social distancing, antiviral prophylaxis, school closure, and vaccination are likely to be cost-effective in all settings, while quarantine is never cost-effective.…”

Section: Resultsmentioning

confidence: 99%

“…Two systematic reviews, both from the 2009 pandemic, report on the cross-protection of seasonal influenza vaccines against pandemic influenza infection for the three Northern hemisphere influenza seasons between 2007 and 2010 and the two Southern hemisphere influenza seasons between 2008 and 2009 [32, 37]. Li et al .…”

Section: Resultsmentioning

confidence: 99%

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Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis

2016

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BackgroundInfluenza pandemics occur when a novel influenza strain, to which humans are immunologically naïve, emerges to cause infection and illness on a global scale. Differences in the viral properties of pandemic strains, relative to seasonal ones, can alter the effectiveness of interventions typically implemented to control seasonal influenza burden. As a result, annual control activities may not be sufficient to contain an influenza pandemic.PurposeThis study seeks to inform pandemic policy and planning initiatives by reviewing the effectiveness of previous interventions to reduce pandemic influenza transmission and infection. Results will inform the planning and design of more focused in-depth systematic reviews for specific types of interventions, thus providing the most comprehensive and current understanding of the potential for alternative interventions to mitigate the burden of pandemic influenza.MethodsA systematic review and narrative synthesis of existing systematic reviews and meta-analyses examining intervention effectiveness in containing pandemic influenza transmission was conducted using information collected from five databases (PubMed, Medline, Cochrane, Embase, and Cinahl/EBSCO). Two independent reviewers conducted study screening and quality assessment, extracting data related to intervention impact and effectiveness.Results and DiscussionMost included reviews were of moderate to high quality. Although the degree of statistical heterogeneity precluded meta-analysis, the present systematic review examines the wide variety of interventions that can impact influenza transmission in different ways. While it appears that pandemic influenza vaccination provides significant protection against infection, there was insufficient evidence to conclude that antiviral prophylaxis, seasonal influenza cross-protection, or a range of non-pharmaceutical strategies would provide appreciable protection when implemented in isolation. It is likely that an optimal intervention strategy will employ a combination of interventions in a layered approach, though more research is needed to substantiate this proposition.Trial RegistrationPROSPERO 42016039803

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Section: Resultsmentioning

confidence: 58%