Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats

Tyagi, Anupama; Kumar, Uday; Santosh, Vadakattu S.; Reddy, Suryam; Mohammed, Saazida Bhanu; Ibrahim, Ahamed

doi:10.1016/j.plefa.2014.09.003

Cited by 16 publications

(11 citation statements)

References 51 publications

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“…; Tyagi et al . ). This discrepancy is most probably due to the amount of n‐3 PUFAs administered, as too much dietary fat could be harmful in colitis even if the type of fat is n‐3 PUFAs (Hokari et al .…”

Section: Discussionmentioning

confidence: 97%

“…There is a growing body of evidence supporting the antioxidant and anti-inflammatory effect of n-3 PUFAs, such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Serhan & Savill 2005;Calder 2006aCalder ,b, 2008Fetterman & Zdanowicz 2009;Tjonneland et al 2009;Hou et al 2011). The anti-inflammatory effect of n-3 PUFAs was investigated in both human clinical trials and animal models of colitis with conflicting results (Yuceyar et al 1999;Nieto et al 2002;Andoh et al 2003;Serhan & Savill 2005;Calder 2006a,b;Chapkin et al 2007;Tjonneland et al 2009;Hou et al 2011;Marion-Letellier et al 2013) In DSS-induced colitis, n-3 PUFAs have been reported to have both ameliorating and aggravating effects (Hokari et al 2013;Tyagi et al 2014). This discrepancy is most probably due to the amount of n-3 PUFAs administered, as too much dietary fat could be harmful in colitis even if the type of fat is n-3 PUFAs (Hokari et al 2013).…”

Section: Discussionmentioning

confidence: 99%

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Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats

Triantafyllidis

Poutahidis

Taitzoglou

et al. 2015

Int J Experimental Path

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Oxidative damage is a central feature of ulcerative colitis. Here, we tested whether the antioxidant Mesna, when administered alone or in combination with n-3 polyunsaturated fatty acids (n-3 PUFAs), affects the outcome of dextran sodium sulphate (DSS)-induced ulcerative colitis in rats. After the induction of colitis, DSS-treated rats were further treated orally (p.o), intraperitoneally (i.p) or intrarectally (i.r) for either 7 or 14 days with Mesna, n-3 PUFAs or both. Rats were euthanized at the end of each treatment period. Clinical disease activity index was recorded throughout the experiment. At necropsy colorectal gross lesions were scored. Colitis was scored histologically, and the expression of myeloperoxidase (MPO), caspase-3, inducible nitric oxide synthase (iNOS) and nuclear factor κB (NF-κΒ) in colonic tissue was assessed by immunohistochemistry. Mesna alone was sufficient to significantly reduce colorectal tissue damage when administered orally or intraperitoneally. Orally coadministered n-3 PUFAs enhanced this effect, resulting in the significant suppression of DSS colitis after 7 days, and a remarkable recovery of colorectal mucosa was evident after 14 days of treatment. The amelioration of colon pathology co-existed with a significant decrease in MPO expression, overexpression of iNOS and reduction of nuclear NF-κB p65 in inflammatory cells, and the suppression of apoptosis in colonic epithelial cells. The simultaneous administration of Mesna and n-3 PUFAs is particularly effective in ameliorating DSS colitis in rats, by reducing oxidative stress, inflammation and apoptosis, probably through a mechanism that involves the inhibition of NF-κB and overexpression of iNOS.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats

Triantafyllidis

Poutahidis

Taitzoglou

et al. 2015

Int J Experimental Path

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“…Overall, the bacterial response a LCPUFA induces (i.e., bacterial survival, dysbiosis) ( 251 , 270 , 273 , 308 – 310 ), depends on the type of infectious agent ( 6 , 260 ), diversity and richness of gut microbiota ( 311 ), and the n -3: n- 6 dietary LCPUFA ratio ( 312 , 313 ). In C57BL/6J mice fed with high-fat diets for 5 weeks (high corn oil, n -6 PUFA; corn oil + fish oil; supplemented n -3 PUFA; and low fat control, n -6 PUFA; 5% corn oil) and infected with Citrobacter rodentium to induce colitis, both high-fat diets reduced Bacteroides spp.…”

Section: Long-chain Fatty Acidsmentioning

confidence: 99%

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

et al. 2016

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Numerous reviews have discussed gut microbiota composition changes during inflammatory bowel diseases (IBD), particularly Crohn's disease (CD). However, most studies address the observed effects by focusing on studying the univariate connection between disease and dietary-induced alterations to gut microbiota composition. The possibility that these effects may reflect a number of other interconnected (i.e., pantropic) mechanisms, activated in parallel, particularly concerning various bacterial metabolites, is in the process of being elucidated. Progress seems, however, hampered by various difficult-to-study factors interacting at the mucosal level. Here, we highlight some of such factors that merit consideration, namely: (1) the contribution of host genetics and diet in altering gut microbiome, and in turn, the crosstalk among secondary metabolic pathways; (2) the interdependence between the amount of dietary fat, the fatty acid composition, the effects of timing and route of administration on gut microbiota community, and the impact of microbiota-derived fatty acids; (3) the effect of diet on bile acid composition, and the modulator role of bile acids on the gut microbiota; (4) the impact of endogenous and exogenous intestinal micronutrients and metabolites; and (5) the need to consider food associated toxins and chemicals, which can introduce confounding immune modulating elements (e.g., antioxidant and phytochemicals in oils and proteins). These concepts, which are not mutually exclusive, are herein illustrated paying special emphasis on physiologically inter-related processes.

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“…Simopoulos [41] also reported that an n-6/n-3 ratio of the of 3 : 1 was correlated to suppression of the inflammatory process in patients with rheumatoid arthritis and a ratio of 5 : 1 promoted beneficial effects in patients with asthma, suggesting that the optimal ratio may vary according to disease under consideration. In a model of DSS-induced intestinal inflammation in rats, the dietary n-6/n-3 fatty acid ratio between 10 and 5 significantly attenuated the severity of colon inflammation, supressing TNF-α and IL-1β production [42]. These results corroborated our finding because BPE-CO 2 A contains an n-6/n-3 ratio of 6 : 1, a low ratio that can explain its protective effects on the TNBS-induced intestinal damage.…”

Section: ]mentioning

confidence: 96%

Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats

et al. 2020

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Bidens pilosa is an herb popularly used to treat inflammation, hemorrhoids, fever, and gastric ulcers with reported pharmacological activities and chemical composition that sustain its selection as a potential intestinal anti-inflammatory product. Based on this, we examined the effects of a B. pilosa fatty acid-standardized supercritical preparation on the intestinal inflammatory process induced by trinitrobenzenesulphonic acid in rats, using either preventative or curative treatments. We also investigated the safety of plant extract by acute and sub-chronic toxicological analysis. The intestinal anti-inflammatory activity was related to modulation of the immune response, increasing IL-10 production and reducing IL-1β, IL-6, and TNF-α level, the oxidative stress, and the MUC production in the inflamed colon. Optic, scanning, and transmission electron microscopy (TEM) analysis supported the beneficial effects promoted by B. pilosa, which were closely related to downregulation of heparanase, Hsp70, Mapk 3, and NF-κB signaling and with the presence of long-chain fatty acids in extract. Our data suggest that B. pilosa supercritical preparation is a chemically standardized preparation potentially useful as complementary intestinal anti-inflammatory agent to treat inflammatory bowel disease.

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Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats

Cited by 16 publications

References 51 publications

Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats

Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats

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