Partial restriction of genome expression — a component of its work reprogramming in regenerating liver of mammals

Levels of rna for TNF-α and receptors during the prereplicative period of liver regeneration

“…One of the striking peculiari ties of this stage is the partial restriction and partial activation of geno me expression. The former manifests itself in a decreased complexity of the nuclear RNA transcribed from protein-coding DNA sequences, delayed transit of newly formed RNA from nucleus to cytoplasm, release of ribosomes from the endoplasmic reticulum [32], and an increased cytoplas mic activity of 2',5'-oligo (A) synthetase with the tendency to produce oli gomers longer than the enzyme from unstimulated livers (unpublished data). It is known that the efficiency to stimulate RNAse L increases with the length of the 2',5'-oligoadenylate molecules [33].…”

“…Thus, a qualitati vely changing cell population of the regenerating liver [31] may lead to a variable response pattern of the whole organ. These changes are temporally limited to the stage of the prereplicative period classified as reorientation of cellular metabolism [32]. One of the striking peculiari ties of this stage is the partial restriction and partial activation of geno me expression.…”

The potential targets of Kupffer cells activity during liver regeneration

“…0.5-3 h after PHE) and a Gl-like period (ca. 3-12 h after PHE) [12]. The G2 and M phases in hepatocytes have standard periods of 4.5 h and 1 h, respectively.…”

“…The ribosomes tran siently lose attachment to the rough endoplasmatic reticulum. The restoration of the typical structure of the latter begins 1 h after PHE [12].…”