Partial Sensory Denervation of the Upper Respiratory Tract on Allergen- and Histamine-Induced Bronchoconstriction

Zimmermann, I.; Almeida, A. A. Bugalho de; Ulmer, W. T.

doi:10.1159/000194646

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In experiments involving stimulation of the superior laryngeal nerve, it seems likely that there is a large number of affer ent fibers in the superior laryngeal nerve which originate from the mucosa of the upper larynx [Dunker et al, 1972], The prophylactic effect of transection of supe rior laryngeal nerve on antigen-induced bronchoconstriction originating in the upper respiratory tract makes it likely that this nerve is responsible for the sensoric innervation of the upper airtract [Zimmermann et al, 1984] and supports the hypo thesis that sensoric innervation and affer ent pathways, running through the nervus vagus are connected.…”

Section: Discussionmentioning

confidence: 99%

Influence of a Minimal Surgical Transection around the Trachea on Bronchoconstriction in Cats

Zimmermann¹,

Ulmer²

1984

Respiration

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The influence of a minimal surgical transection around the trachea on ACH- and allergen-induced bronchoconstriction was studied in a series of 21 cats. A significant smaller bronchoconstriction was observed after surgical transection around the trachea. The trachea isolation itself induced a smaller nonsignificant bronchoconstrictive response. This diminished response of the airways after this surgical intervention assumes an interruption of syncytial connections, which alters the response to bronchoconstricting stimuli of the whole bronchial system. The exact role of these syncytial connections has yet to be clarified

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Section: Discussionmentioning

confidence: 99%

Influence of a Minimal Surgical Transection around the Trachea on Bronchoconstriction in Cats

Zimmermann¹,

Ulmer²

1984

Respiration

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Changes in Upper and Lower Airway Resistance After Inhalation of Antigen in Sensitized Rats

Bellofiore¹,

Maria²,

Martin³

1987

Am Rev Respir Dis

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To assess the contribution of upper and lower airways to the changes in pulmonary resistance after inhalation of antigen by sensitized rats, we measured changes in upper airway resistance (Ru) and lower pulmonary resistance (Rlo) after inhalation of ovalbumin (OA) in anesthetized, spontaneously breathing, sensitized BN rats. Aerosols of antigen were inhaled through the nose and through a tracheostomy in random order; there was a 1-h recovery interval between challenges. After inhalation of OA through the nose, Ru increased from 0.441 +/- 0.057 (mean +/- 1 SE) to 1.342 +/- 0.504 cm H2O X ml-1 X s (n = 6; p less than 0.05) and Rlo increased from 0.099 +/- 0.017 to 0.269 +/- 0.08 cm H2O X ml-1 X s (p less than 0.05). Changes in Ru and Rlo were strongly correlated (r = 0.938; p less than 0.001). After OA was inhaled through the tracheostomy, Rlo increased from 0.089 +/- 0.021 to 0.152 +/- 0.041 cm H2O X ml-1 X s (p less than 0.05). However, Ru did not change significantly. Pretreatment of the lower airways with inhaled atropine did not affect the magnitude of the changes in Ru after inhalation of OA through the nose but significantly attenuated the response of the lower airways. We conclude that when sensitized, spontaneously breathing rats inhale antigen through the nose, the predominant reaction occurs in the upper airways; changes in upper airway resistance do not result from reflexes originating in the lower airways; lower airway responses are mediated in part by cholinergic mechanisms.

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Partial Sensory Denervation of the Upper Respiratory Tract on Allergen- and Histamine-Induced Bronchoconstriction

Cited by 2 publications

References 7 publications

Influence of a Minimal Surgical Transection around the Trachea on Bronchoconstriction in Cats

Influence of a Minimal Surgical Transection around the Trachea on Bronchoconstriction in Cats

Changes in Upper and Lower Airway Resistance After Inhalation of Antigen in Sensitized Rats

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