Partial splenectomy in cystic fibrosis patients with hypersplenism

A novel spleen-preserving laparoscopic technique using radiofrequency ablation in a porcine model

“…Benign tumors [19], cysts [6,7,18], trauma [17,19], pseudocysts [2], biopsies [5,14,17], cystic fibrosis [16], hydatid cyst [1], GaucherÕs disease [10], and hereditary hemolytic anemias with hypersplenism [13] have all been treated with partial splenectomy with different degrees of success.…”

Outcome of total splenectomy with portosystemic shunt for massive splenomegaly and variceal bleeding in cystic fibrosis

“…It displays a slowly progressive course [20]. About 7% of CF patients will develop clinically obvious portal hypertension [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. How many evolve to hepatic function failure is still not well established, but from practice, it seems rare [1].…”

“…Variceal hemorrhage is the most life-threatening symptom of portal hypertension. Although sclerotherapy or banding can control acute bleeding, it usually provides only temporary relief [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hypertensive gastropathy and gastric varices cannot be treated with these techniques.…”

“…For patients with decompensated liver disease, evidenced by progressive hypoalbuminemia and vitamin K-independent coagulopathy, orthotopic liver transplantation is the only solution [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. In these patients, portosystemic shunting can result in encephalopathy [10].…”

“…To obtain a more permanent decrease of the splanchnic pressure, various techniques are used (transjugular intrahepatic portosystemic stent shunt [TIPSS] [7,8], nonshunt operations [9], surgical construction of a portosystemic shunt [10], or a splenorenal shunt [11] However if present, massive splenomegaly remains a problem and can cause important abdominal discomfort, gastric compression leading to impaired nutritional intake. Different techniques to reduce the spleen volume have been attempted, including partial embolization [12] and partial or total splenectomy [13,14].…”