Partial tablet coating by 3D printing

Tsintavi, Eleni; Rekkas, Dimitrios M.; Bettini, Ruggero

doi:10.1016/j.ijpharm.2020.119298

Cited by 25 publications

(10 citation statements)

References 45 publications

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“…3DP in drug production possesses patient-customized characteristics as well as accomplishes the selection of drug size, shape, and combination of different pharmaceutical ingredients, which may be more convenient for clinical applications [119] . Through 3DP technology, even the layers and percentage parameters in tablet coating, therapeutic release rates and patterns can also be predesigned, thus providing better curative effects [120,121] .…”

Section: Ai In Drug Productionmentioning

confidence: 99%

Application of Artificial Intelligence in Medicine: An Overview

et al. 2021

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Artificial intelligence (AI) is a new technical discipline that uses computer technology to research and develop the theory, method, technique, and application system for the simulation, extension, and expansion of human intelligence. With the assistance of new AI technology, the traditional medical environment has changed a lot. For example, a patient’s diagnosis based on radiological, pathological, endoscopic, ultrasonographic, and biochemical examinations has been effectively promoted with a higher accuracy and a lower human workload. The medical treatments during the perioperative period, including the preoperative preparation, surgical period, and postoperative recovery period, have been significantly enhanced with better surgical effects. In addition, AI technology has also played a crucial role in medical drug production, medical management, and medical education, taking them into a new direction. The purpose of this review is to introduce the application of AI in medicine and to provide an outlook of future trends.

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Section: Ai In Drug Productionmentioning

confidence: 99%

Application of Artificial Intelligence in Medicine: An Overview

et al. 2021

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“…Researchers can then use the model to predict what variable settings will result in an optimal outcome. To date, DoE in 3DP of pharmaceuticals has been applied to evaluate structure-function relationships of various parameters for FDM, SLS and SSE [127][128][129][130][131].…”

Section: Design Of Experimentsmentioning

confidence: 99%

Harnessing artificial intelligence for the next generation of 3D printed medicines

Elbadawi

McCoubrey

Gavins

et al. 2021

Advanced Drug Delivery Reviews

110

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The calorimeter was equipped with an autosampler and refrigerating cooling accessory, enabling the measurements from −90 • C. Calibration of the calorimeter was performed via utilization of In, Zn, and H 2 O melting temperatures and enthalpies. All samples were measured hermetically sealed in low-mass aluminum pans, which in fact ensured exposition to static air atmosphere during the measurement (note that the DSC cell was still purged with a continuous 50 cm 3 •min −1 N 2 flow to ensure the steady conditions and to minimize the fluctuation of thermal gradients). The sample masses were approximately 5 mg.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…It is generally known that alcohol can change or totally destroy the drug release mechanism, which can result in an immediate and uncontrolled release of the active pharmaceutical substance (API) from the dosage form [2][3][4]. This process is called the alcohol-induced dose dumping (ADD) effect.…”

Section: Introductionmentioning

confidence: 99%

“…They applied the coating system from cellulose acetate in the form of the 3D-printed encapsulating shell for the coating of the tablets containing propranolol hydrochloride. The aim of the work of Tsintavi and co-workers [3] was to partially coat tablets with Precirol ATO 5 using a semi-solid 3D printer and, in this way, to modify the release of two APIs: the hydrophilic methyl-levodopa (Melevodopa) and lipophilic Acyclovir. Their work demonstrated that glycerides can be used for the partial coating of tablets to modify the release rate of the two above-mentioned drugs, without the need to change the tablet composition.…”

Section: Introductionmentioning

confidence: 99%

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3D-Printed Coating of Extended-Release Matrix Tablets: Effective Tool for Prevention of Alcohol-Induced Dose Dumping Effect

et al. 2021

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Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of the release mechanism in the presence of alcohol due to the possible occurrence of the dose dumping effect. The effect of 3D printing (3DP) coating on the drug release mechanism and the drug release rate was studied as a possible tool for the prevention of the alcohol-induced dose dumping effect. Three types of matrix tablets (hydrophilic, lipophilic, and hydrophilic-lipophilic) were prepared by the direct compression method and coated using 3DP. The commercial filament of polyvinyl alcohol (PVA) and the filament prepared from hypromellose by hot melt extrusion (HME) were used as coating materials. Both coating materials were characterized by SEM, DSC, Raman spectroscopy, and PXRD during particular stages of the processing/coating procedure. The dissolution behavior of the uncoated and coated tablets was studied in the strongly acidic (pH 1.2) and alcoholic (40% of ethanol) dissolution media. The dissolution tests in the alcoholic medium showed that the Affinisol coating was effective in preventing the dose dumping incidence. The dissolution tests in the acidic dissolution media showed that the Affinisol coating can also be useful for the delayed release of active substances.

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Partial tablet coating by 3D printing

Cited by 25 publications

References 45 publications

Application of Artificial Intelligence in Medicine: An Overview

Application of Artificial Intelligence in Medicine: An Overview

Harnessing artificial intelligence for the next generation of 3D printed medicines

3D-Printed Coating of Extended-Release Matrix Tablets: Effective Tool for Prevention of Alcohol-Induced Dose Dumping Effect

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