Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney

Ayan, Semih; Roth, Jonathan V.; Freeman, Michael R.; Bride, Samuel H.; Peters, Craig A.

doi:10.1016/s0090-4295(01)01156-6

Cited by 22 publications

(15 citation statements)

References 23 publications

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“…Ureteral obstruction causes renin secretion to rise (21,27,28) (14). Ishidoya et al showed the importance that the RAS has for renal fibrosis, using an Ang II receptor antagonist and an ACE inhibitor for its suppression (18 Kagami et al (20), and Pimentel et al (29) reported that the elevated TGF-b seen in obstruction is mediated by Ang II.…”

Section: Discussionmentioning

confidence: 99%

Diuretic Renography in Hydronephrosis: Delayed Tissue Tracer Transit Accompanies Both Functional Decline and Tissue Reorganization

Schlotmann¹,

Clorius²,

Rohrschneider³

et al. 2008

J Nucl Med

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The significance of delayed tissue tracer transit (TTT) of 99m Tcmercaptoacetyltriglycine ( 99m Tc-MAG3) has not been systematically evaluated in hydronephrosis. We sought to demonstrate that delayed TTT accompanies both functional decline and histomorphologic restructuring. Methods: Twenty 2-to 3-mo-old piglets with surgically induced partial unilateral ureteral stenosis were examined with magnetic resonance urography (MRU) to evaluate morphology and with 99m Tc-MAG3 diuretic renography (DR) to determine single-kidney function (SKF), evaluate the response to furosemide stimulation (RFS), and assess TTT. All animals had DR and MRU before and after surgery and a third DR after surgery. Piglets were sacrificed after the final DR for renal histology. A total histologic score (THS) was generated. Results: Preoperative DR demonstrated nonobstructive RFS, timely TTT, and balanced SKF in all 20 kidneys. After ureteral ligature, MRU demonstrated pelvic dilatation in all piglets. The postoperative DRs revealed 12 kidneys with delayed TTT in one or both followups. In these 12 kidneys, the SKF declined from 51% 6 4% to 18% 6 14%, and the THS was 9.0 6 4.0. Three kidneys always had timely TTT, balanced SKF, and a THS of 1.8 6 0.3. The contralateral, nonoperated kidneys had timely TTT and a THS of 1.2 6 0.9. Postoperative scintigrams showed that 3 of 8 kidneys (38%) with an obstructive RFS had timely TTT, which demonstrates that TTT and RFS are not equivalent. Conclusion: In hydronephrosis, a delayed TTT of 99m Tc-MAG3 accompanies both functional decline and histomorphologic restructuring in obstruction. According to the literature, a delayed TTT is determined by the filtration fraction of the kidneys and appears to identify an obstruction-mediated upregulated renin-angiotensin system.

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Section: Discussionmentioning

confidence: 99%

Diuretic Renography in Hydronephrosis: Delayed Tissue Tracer Transit Accompanies Both Functional Decline and Tissue Reorganization

Schlotmann¹,

Clorius²,

Rohrschneider³

et al. 2008

J Nucl Med

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“…Under basal conditions, renin produced by juxtaglomerular cells is sufficient to main BP and intravascular volume (71). Upon prolonged threat to volume homeostasis (i.e., through exposing mice to a low salt diet and ACE inhibitors) additional cells along afferent arterioles express renin, in angiotensinogen-deficient mice renin is even expressed by fibroblasts (pericytes) all through the kidney cortex (80,81). Models of CKD are also associated with recruitment of additional renin-producing cells.…”

Section: Reninmentioning

confidence: 99%

Physiology of the Renal Interstitium

Zeisberg

Kalluri

2015

Clinical Journal of the American Society of Nephrology

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Long overlooked as the virtual compartment and then strictly characterized through descriptive morphologic analysis, the renal interstitium has finally been associated with function. With identification of interstitial reninand erythropoietin-producing cells, the most prominent endocrine functions of the kidney have now been attributed to the renal interstitium. This article reviews the functional role of renal interstitium.

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“…Functionally, AT2 receptors are believed to mediate programmed cell death (Yamada et al 1996), while AT1 receptor activation has been linked to proliferative/hypertrophic responses. It should not be surprising that the renin-angiotensin system also plays a direct role in the anomalous development of the upper urinary tract in the setting of ureteral obstruction (Ayan et al 2001).…”

Section: Local Renin-angiotensin Systemsmentioning

confidence: 99%

“…Obstruction of the bladder outlet and the ureter in the fetal sheep has been linked to upregulation of the renal RAS, with elevated levels of renin, angiotensinogen, and AT1 receptor mRNA (Ayan et al 2001). In addition, downstream effectors were also increased, including TGF-ß, PDGF, and HBEGF (Park et al 1998), as well as in tissue inhibitors of metalloproteinases (Peters et al 1992b;Gobet et al 1999).…”

Section: Local Renin-angiotensin Systemsmentioning

confidence: 99%

Local renin–angiotensin systems in the genitourinary tract

Comiter¹

2011

Naunyn-Schmiedeberg's Arch Pharmacol

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Local renin-angiotensin systems are common throughout the human body. Recent evidence supports the existence of such local renin-angiotensin systems in the penis, clitoris, bladder, ureter, internal anal sphincter, and urethral sphincter. Beyond its role in regulating blood pressure through its effects on vascular tone, sodium balance, and fluid homeostasis, angiotensin II serves a key role in affecting physiologic and pathophysiologic activities of the genitourinary tract. Just as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are used for the treatment and prevention of heart disease and vascular disease, inhibition of excessive angiotensin II activity may be potentially useful for the treatment of urologic disorders.

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Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney

Cited by 22 publications

References 23 publications

Diuretic Renography in Hydronephrosis: Delayed Tissue Tracer Transit Accompanies Both Functional Decline and Tissue Reorganization

Diuretic Renography in Hydronephrosis: Delayed Tissue Tracer Transit Accompanies Both Functional Decline and Tissue Reorganization

Physiology of the Renal Interstitium

Local renin–angiotensin systems in the genitourinary tract

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