Partial versus radical nephrectomy for T1b-2N0M0 renal tumors: A propensity score matching study based on the SEER database

Zhang, Mengping; Zhao, Zhijian; Duan, Xiaolu; Deng, Tuo; Cai, Chao; Zeng, Guohua

doi:10.1371/journal.pone.0193530

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…Multiple studies have assessed the survival of patient undergoing partial vs. radical nephrectomy and found that partial nephrectomy is associated with a better overall survival as well as cancer specific survival. However, populations with specific cancer stages, T1b and T2, were the populations demonstrating better survival outcomes following partial nephrectomy (36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Saad

Gad

Al‐Husseini

et al. 2019

Clinical Genitourinary Cancer

156

112

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Background: Renal cell carcinoma (RCC) is one of the common malignancies in the United States. RCC incidence and mortality have been changing due to many reasons. We provide a thorough investigation of incidence and mortality trends of RCC in the US using the surveillance, epidemiology and end results (SEER) database. Methods: The SEER 13 registries were accessed for RCC cases diagnosed between 1992 and 2015. Incidence and mortality were calculated by demographic and tumor characteristics. We calculated annual percent changes (APC) of these rates. Rates were expressed by 100,000 personyears. Results: A total of 104,584 RCC cases were reviewed with 47,561 deaths. The overall incidence was 11.281 per 100,000 person-years. Incidence increased by 2.421% per year (95% CI, 2.096-2.747, p<.001) but later became stable since 2008. However, the incidence of clear-cell subtype continued to increase (1.449%; 95% CI, 0.216-2.697, P=.024). RCC overall mortality rates have been declining since 2001. However, mortality associated with distant RCC only started to decrease in 2012 with APC of −18.270% (−28.775-6.215, P = .006)

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Section: Discussionmentioning

confidence: 99%

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Saad

Gad

Al‐Husseini

et al. 2019

Clinical Genitourinary Cancer

156

112

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“…In the present study, no significant differences in 5-year and 10-year OS were found between the PN and the RN groups for the treatment of T1b renal tumors. Zhang et al found that OS was independent of the type of surgical procedure in the propensity score matching [27].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

et al. 2019

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Background The efficacy of partial nephrectomy (PN) for T1b renal cell carcinoma (RCC) is controversial. The oncological outcomes, the change in postoperative renal function and the perioperative complications are unclear. Methods We searched PUBMED, EMBASE and the Cochrane Central Register for studies from March 1998 to March 2018 for studies comparing PN to radical nephrectomy (RN) for the treatment of T1b RCC. After data extraction and quality assessment, we used RevMan 5.2 to pool the data. Then, we used Stata 12.0 to perform sensitivity analyses and meta-regression. We used the GRADE profiler to evaluate the evidence according to the GRADE approach. Results A total of 16 studies involving 33,117 patients were included in our meta-analysis. No significant difference was found in the 5-year overall survival (OS), 10-year OS, 5-year recurrence-free survival (RFS) and 10-year RFS. The 5-year cancer-special survival (CSS) and 10-year CSS were better in RN compared to PN, respectively, at RR = 1.02, P < 0.05 and RR = 1.04, P < 0.05. PN was better than RN in the preservation of renal function (WMD = -9.15, 95% CI: − 10.30 to − 7.99, P < 0.05). The confidence level grading of the evidence was moderate for 5-year OS, 10-year OS, 5-year CSS, 10-year CSS, 5-year RFS, 10-year RFS, tumor recurrence, decline in eGFR, and postoperative complications. Conclusions PN may provide comparable outcomes in terms of RFS & OS, and better renal function preservation although CSS was worse. Electronic supplementary material The online version of this article (10.1186/s12894-019-0480-6) contains supplementary material, which is available to authorized users.

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“…As the oncological outcomes had been adjusted for confounders, we extracted oncological outcomes from the study [ 22 ] for its larger sample size. There were several studies based on data accessed from a national database [ [9] , [10] , [11] , [12] , [13] , 23 , 24 ], and we excluded all of these because of the potential data duplication and inner heterogeneity of medical institutions.…”

Section: Methodsmentioning

confidence: 99%

“…The role of PN still needs to be confirmed for T1b (4–7 cm) renal masses. Several analyses of the Surveillance, Epidemiology, and End Results (SEER) database have suggested that PN provides equivalent cancer control to RN for both T1b and T2 renal masses [ [9] , [10] , [11] , [12] , [13] ], but PN use still remains limited in both Europe [ 14 ] and the USA [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the oncological, perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma: A systematic review and meta-analysis of retrospective studies

Zhang

Long

Shang

et al. 2021

Asian Journal of Urology

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Objective To conduct a meta-analysis assessing the perioperative, functional and oncological outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for T1b tumours. The primary endpoints were the oncological outcomes. The secondary endpoints were the perioperative and functional outcomes. Methods A systematic literature review was performed by searching multiple databases through February 2019 to identify eligible comparative studies according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Identified reports were assessed according to the Newcastle-Ottawa Scale for nonrandomized controlled trials. Results Overall, 13 retrospective cohort studies were included in the analysis. Patients undergoing PN were younger (weighted mean difference [WMD] −3.49 years, 95% confidence interval [CI] −5.16 to −1.82; p <0.0001) and had smaller masses (WMD −0.45 cm, 95% CI −0.59 to −0.31; p <0.0001). There were no differences in the oncological outcome, which was demonstrated by progression-free survival (hazard ratio [HR] 0.70; p =0.22), cancer-specific mortality (HR 0.91; p =0.57) and all-cause mortality (HR 1.01; p =0.96). The two procedures were similar in estimated blood loss (WMD −16.47 mL; p =0.53) and postoperative complications (risk ratio [RR] 1.32; p =0.10), and PN provided better renal function preservation and was related to a lower likelihood of chronic kidney disease onset (RR 0.38; p =0.006). Conclusion PN is an effective treatment for T1b tumours because it offers similar surgical morbidity, equivalent cancer control, and better renal preservation compared to RN.

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Partial versus radical nephrectomy for T1b-2N0M0 renal tumors: A propensity score matching study based on the SEER database

Cited by 9 publications

References 24 publications

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis

Comparison of the oncological, perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma: A systematic review and meta-analysis of retrospective studies

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