Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells

Jang, Ji Yeon; Kim, Ha‐Neui; Kim, Yu Ri; Choi, Woo-Yong; Choi, Yung Hyun; Shin, Hwa Kyoung; Choi, Byung Tae

doi:10.1016/j.jep.2011.07.047

Cited by 44 publications

(26 citation statements)

References 26 publications

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“…However, quercetin and eriodictyol, which have substituents on the C ring that differ from that of luteolin, showed no extracellular melanogenesis inhibitory activity. In addition, apigenin, chrysin, activity [21][22][23]. In particular, the determination of the downregulation of the expression of activated p38 and MITF is commonly used to investigate the mechanism by which compounds inhibit melanogenesis [21,24].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Helminthostachys zeylanica roots

et al. 2015

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Section: Accepted Manuscriptmentioning

confidence: 99%

Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Helminthostachys zeylanica roots

et al. 2015

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“…PKA phosphorylates the cAMP response element-binding protein (CREB), which is known to be an activator of MITF expression [16,[21][22][23]. Phosphorylated p38 MAPK stimulates the expression of melanogenic enzymes via activating the MITF expression [24,25].…”

Section: Transcriptional Regulation Of Melanogenesismentioning

confidence: 99%

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Mitsunaga

Yamauchi

2015

J Wood Sci

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Controlling melanogenesis is important for maintaining the good health and cosmetic appearance of a human body. This study aims to search the active compounds from natural products exhibiting the melanogenesis modulating activity and elucidate the mechanism underlying the observed activity. Two novel quercetin glycosideswere isolated and identified from Helminthostachys zeylanica roots 50 % ethanol extract. Compound 1 exhibited intracellular melanogenesis stimulatory activity, while 2 showed no effect even the structural similarity. To understand the structure-activity relationships, twelve quercetin glycosides and seven methylquercetins were synthesized from rutin as starting material. As the result of bioassay using synthesized nineteen quercetin derivatives in B16 melanoma cells, some quercetin-3-O-b-D-glucopyranosides stimulated the intracellular melanogenesis. On the other hand, synthesized 3-O-methylquercetin 12 and 3,4 0 ,7-Otrimethylquercetin 15 increased both intra and extracellular melanin contents with no cytotoxicity. Compoud 15 increased the phosphorylated p38 mitogen-activated protein kinase (MAPK) and microphthalmia-associated transcription factor (MITF) which regulates the expression of tyrosinase, TRP-1 and TRP-2. While 12 enhanced the expression of the melanogenic enzymes without involving the MITF, as evidenced by its lack of any stimulation of the expression of MITF and p-p38 MAPK. This result indicates that 12 may stimulate the expression of tyrosinase, TRP-1, and TRP-2 by stimulating currently unidentified transcriptional factors and/or by regulating the degradation of melanogenic enzymes.

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“…Mitogen‐activated protein kinase (MAPK) signalling is also a key modulator of melanogenesis through its regulation of MITF activation 13. Phosphorylation of extracellular‐signal‐regulated kinases (ERK), c‐Jun N‐terminal kinase (JNK) and p38 MAPK lead to MITF ubiquitination and degradation, and thus inhibit melanin production 14, 15, 16, 17.…”

Section: Introductionmentioning

confidence: 99%

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways

Baek

Lee

2015

Experimental Dermatology

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The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasma, freckles, age spots and chloasma. The aim of this study was to investigate the antimelanogenic effect of sesamol, an active lignan isolated from Sesamum indicum, in melan‐a cells. Sesamol strongly inhibited melanin biosynthesis and the activity of intracellular tyrosinase by decreasing cyclic adenosine monophosphate (cAMP) accumulation. Sesamol significantly decreased the expression of melanogenesis‐related genes, such as tyrosinase, tyrosinase‐related protein‐1,2 (TRP‐1,2), microphthalmia‐associated transcription factor (MITF) and melanocortin 1 receptor (MC1R). In addition, sesamol also induces phosphorylation of p38 mitogen‐activated protein kinase (p38 MAPK) and c‐Jun N‐terminal kinase (JNK). Moreover, sesamol dose‐dependently decreased zebrafish pigment formation, tyrosinase activity and expression of melanogenesis‐related genes. These findings indicate that sesamol inhibited melanin biosynthesis by down‐regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis‐related proteins through modulation of MITF activity, which promoted phosphorylation of p38 and JNK in melan‐a cells. Together, these results suggest that sesamol strongly inhibits melanin biosynthesis, and therefore, sesamol represents a new skin‐whitening agent for use in cosmetics.

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Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells

Cited by 44 publications

References 26 publications

Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Helminthostachys zeylanica roots

Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Helminthostachys zeylanica roots

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways

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