Partição de biomassa em clones de Eucalyptus na região litorânea do Rio Grande do Norte

Silva, Jucier Magson de Souza e; Silva, Gualter Guenther Costa da; Oliveira, Ermelinda Maria Mota; Oliveira, Paulo Rogério Soares de; Moreira, Thiago de Miranda; Soares, Leonardo Eufrázio; Araújo, Luan Henrique Barbosa de

doi:10.12702/viii.simposfloresta.2014.5-557-1

Anais Do VIII Simpósio Brasileiro De Pós-Graduação Em Ciências Florestais 2014

DOI: 10.12702/viii.simposfloresta.2014.5-557-1

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Partição de biomassa em clones de Eucalyptus na região litorânea do Rio Grande do Norte

Jucier Magson de Souza e Silva

Gualter Guenther Costa da Silva

Ermelinda Maria Mota Oliveira

et al.

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2023

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“…Regarding its pharmacological potential, cis-jasmone has a sedative effect [9], and it has also been shown to be effective for the treatment of chronic ulcerative rectocolitis because of its intestinal anti-neuroinflammatory capacity by acting on the enteric nervous system and because of its tissue repair capacity [10].…”

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Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

et al. 2023

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This study evaluates the pharmacological potential of cis-jasmone (CJ) in adult zebrafish (Danio rerio; aZF). Initially, aZF (n = 6/group) were pretreated (20 µL; p. o.) with CJ (0.1 or 0.3 or 1.0 mg/mL) or vehicle (0.5% Tween 80). The animals were submitted to acute toxicity and locomotion tests, pentylenetetrazole-induced seizure, carrageenan-induced abdominal edema, and cinnamaldehyde-, capsaicin-, menthol-, glutamate-, and acid saline-induced orofacial nociception. The possible mechanisms of anticonvulsant, anxiolytic, and antinociceptive action were evaluated. The involvement of central afferent fibers sensitive to cinnamaldehyde and capsaicin and the effect of CJ on the relative gene expression of TRPA1 and TRPV1 in the brain of aZF were also analyzed, in addition to the study of molecular docking between CJ and TRPA1, TRPV1 channels, and GABAA receptors. CJ did not alter the locomotor behavior and showed pharmacological potential in all tested models with no toxicity. The anticonvulsant effect of CJ was prevented by flumazenil (GABAergic antagonist). The anxiolytic-like effect of CJ was prevented by flumazenil and serotonergic antagonists. The antinociceptive effect was prevented by TRPA1 and TRPV1 antagonists. Chemical ablation with capsaicin and cinnamaldehyde prevented the orofacial antinociceptive effect of CJ. Molecular docking studies indicate that CJ interacted with TRPA1, TRPV1, and GABAA receptors. CJ inhibited the relative gene expression of TRPA1 and TRPV1. CJ has pharmacological potential for the treatment of seizures, anxiety, inflammation, and acute orofacial nociception. These effects are obtained by modulating the GABAergic and serotonergic systems, as well as the TRPs and ASIC channels.

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Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

et al. 2023

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Partição de biomassa em clones de Eucalyptus na região litorânea do Rio Grande do Norte

Cited by 1 publication

References 0 publications

Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

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