Participation GABA-benzodiazepine receptor complex in mechanism of neurotropic action of nicotinamide

Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes

“…Conformational changes in the GABA-BD receptor complex associated with changes in its functional state are determined, among other/actors, by its interaction with the NAD receptor system [2]. Therefore, we studied specific binding of 14C-NAD to synaptic membranes under conditions of morphine dependence and revealed an approximately 20% decrease (Fig.…”

“…Depending on the pathological conditions, this interaction occurs either with or without porticipation of the GABAergic component of the complex [2].…”

Mental Health: Not All in the Mind—Really a Matter of Cellular Biochemistry

“…4 Experiments designed to test the efficacy of nicotinamide and brain function revealed that GA BA nerve receptors were less stimulated when nicotinamide was lacking in the test subjects and that reintroduction of nicotinamide led to a calming effect on the GABA receptors. 5 Supplementation with adequate amounts of nicotinamide may possibly contribute to fewer anxiety symptoms.…”