2017
DOI: 10.1111/1471-0528.14528
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Participation in clinical trials improves outcomes in women's health: a systematic review and meta‐analysis

Abstract: Background Previous reviews examining the effect of participation in trials on outcomes have not consistently shown benefit. Obstetrics and gynaecology is a unique disease area posing challenges for both researchers and patients.Objectives To determine whether participation in randomised controlled trials (RCTs), compared with non-participation, has a beneficial effect on women's health.Search strategy Medline, Embase, the Cochrane Library, and PsycInfo were searched up to December 2015.Selection criteria We s… Show more

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Cited by 61 publications
(52 citation statements)
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References 70 publications
(152 reference statements)
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“…These outcomes suggest that clinical care in early‐onset FGR should be undertaken in tertiary‐level units. It has been shown in many studies that joining trials is of benefit (even in those in which an intervention proves ineffective).…”
Section: What Was the Truffle Study?mentioning
confidence: 99%
“…These outcomes suggest that clinical care in early‐onset FGR should be undertaken in tertiary‐level units. It has been shown in many studies that joining trials is of benefit (even in those in which an intervention proves ineffective).…”
Section: What Was the Truffle Study?mentioning
confidence: 99%
“…Indeed, high access to care has been found to improve the prenatal health of disadvantaged or substance using pregnant women (Aizer and Currie 2014;Kotelchuck et al 2017). Further, being part of a randomized and controlled trial may have had a favorable effect per se (Nijjar et al 2017). However, this finding may also be related to a social desirability bias and other problems in self-reporting within the sample of pregnant women with substance use problems.…”
Section: Discussionmentioning
confidence: 99%
“…Probably all the prenatal services have contributed to the outcomes and, thus the benefits of the studied intervention might have been difficult to differentiate in this setting. In addition, participating in the clinical trial per se may have had a favorable effect on both groups (Nijjar et al 2017).…”
Section: Discussionmentioning
confidence: 99%