Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response

Aim Nutritional changes are often considered first line treatment in public health diseases which apply to many gastrointestinal disorders, since different food and beverages may modulate gastrointestinal (GI) motor and sensory functions, and provoke GI symptoms. The aim of this study was to examine dietary coping and possible changes of food and beverages intakes in relation to GI symptoms reported by identified IBS patients compared to healthy controls and if any gender differences were seen in these respects.Methods A population-based case-control design was used. Three primary health care centres in the city of Linköping in Sweden. The IBS cases were recruited from the studied primary health care centres based on diagnoses from computerized medical records. The controls were randomly selected from the general population in the same region. A questionnaire was used with specific questions about self-reported food and beverages increase or decrease of GI symptoms and self-reported changes in dietary habits.Results Female IBS-cases appear to be more willing to change dietary habits due to their GI-problems than males. Effects of these nutritional behaviour changes were reported for almost all participants that had made dietary adjustments. Fatty food, certain vegetables, dairy products and egg were significantly more reported to cause GI complaints among IBS-cases compared to their controls.Conclusions Female IBS-cases reported more changes in their dietary habits due to GI-problems than males with the disease. The majority of both females and males that changed their dietary habits due to GI problems experienced symptoms improvement.

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“…Eating stimulate different colonic and motor activity that might explain postprandial gastrointestinal symptoms [30,31,32,33,34,35].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in dietary coping with gastrointestinal symptoms

Faresjö¹,

Johansson

Faresjö³

et al. 2010

European Journal of Gastroenterology &Amp; Hepatology

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“…Após a alimentação, tem-se observado um aumento da atividade motora colônica [1][2][3][4][5][6][7] . Este aumento não ocorre em todas as alimentações, mas principalmente depois da primeira alimentação do dia 8 .…”

Section: Introdução Introdução Introdução Introdução Introduçãounclassified

“…Este aumento não ocorre em todas as alimentações, mas principalmente depois da primeira alimentação do dia 8 . Há a hipótese de que a atividade motora colônica, ou mais precisamente do retossigmóide, seja estimulada pela presença dos alimentos 1,3,4,6,7,9,10 . Este aumento na motilidade colônica pós-alimentar tem sido descrito como reflexo gastrocólico [1][2][3][4][5][6]8,[11][12][13][14][15][16] .…”

Section: Introdução Introdução Introdução Introdução Introduçãounclassified

“…A fase gástrica ocorre após a ingestão alimentar, desenvolvendo-se em torno de 30 minutos, podendo persistir por até 3 horas, e a fase intestinal ocorre associada a um aumento da atividade motora no retossigmóide l5 . As evidências sugerem que o reflexo gastrocólico é mediado inicialmente por reflexo neurológico, vindo depois o mecanismo hormonal e finalmente a ação dos quimiorreceptores [7][8][9][10][16][17][18] .…”

Section: Introdução Introdução Introdução Introdução Introduçãounclassified

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Padrão mioelétrico do cólon esquerdo no reflexo gastrocólico

Santos¹,

Ferraz²,

G³

et al. 2000

Rev. Col. Bras. Cir.

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O objetivo deste estudo foi determinar o padrão eletromiográfico do reflexo gastrocólico no cólon esquerdo (sigmóide), através da avaliação da atividade elétrica de controle (AEC), atividade elétrica de resposta (AER) e complexo motor migrante (CMM). Foram avaliadas 15 pacientes, do sexo feminino, submetidas à histerectomia, sem alteração clínica do trato gastrointestinal. A idade média foi de 40,2 anos. As pacientes foram controles de si próprias, tendo sido comparado o período pré com o per e pósprandial. Eletrodos bipolares cobertos por Téflon foram implantados a nível da tênia anterior do cólon esquerdo. Após a recuperação do íleo paralítico, realizou-se a coleta dos dados. Foi utilizado um sistema de aquisição de dados (DATA Q Série 200), que captou frequência entre 0,02 a 10 Hz e um software de análise de dados, (WINDAQ 200) que funcionou no ambiente Windows. Os resultados obtidos evidenciaram que a AEC e AER de curta duração (n/h) não apresentaram diferença estatística. A AER de longa duração (n/h, apresentou uma diminuição estatisticamente significativa. O CMM apresentou aumento estatístico. A conclusão do estudo foi que houve diminuição da atividade elétrica de resposta colônica de longa duração e um aumento da atividade motora do cólon esquerdc após a alimentação.

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“…Balloon distension of the distal stomach evokes an immediate increase in the colonic motor activity which is dependent on cholinergic neural pathways [13,20]. In contrast, contractile activity that occurs 11 h after meal ingestion is only partially atropine sensitive and mediated by other pathways [20].…”

Section: H Pylori Effect ('Gastrocolonic-reflex')mentioning

confidence: 99%

<i>H. pylori</i> Infection and Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome

Gerards

Leodolter²,

Glasbrenner³

et al. 2001

Dig Dis

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Background/Aim: Irritable bowel syndrome (IBS) is characterized by abdominal pain and changes in stool habits. Visceral hypersensitivity (VH) is a key factor in the pathophysiology of IBS. The role of Helicobacter pylori infection in the induction of VH in the upper gastrointestinal tract is controversially discussed. The aim of this study is to evaluate the value of rectal barostat in eliciting abdominal symptoms in patients with IBS in relation to H. pylori infection. Patients and Methods: 31 patients (19 female, 12 male, mean age 45.6 ± 10 years) with normal colonoscopy and clinical signs of IBS were examined by rectal barostat (pressure-controlled balloon distension in the rectum). Induction of typical abdominal discomfort (far from the balloon) defined the examination positive. Level of nonpainful perception (L1), feeling of defecation (L2), and pain or stool urgency (L3) were registered in comparison with a healthy control group (CG; n = 15, 9 female, 6 male). The H. pylori status was defined by ¹³C-urea breath test (n = 46). Results: Typical abdominal discomfort was induced in 9 patients (pain group, PG) by pressure-controlled rectal distension (H. pylori status: 8 positive, 1 negative). Patients not presenting with abdominal pain to rectal distension (nonpain group, NPG) were all H. pylori negative (p < 0.001). L3 as an indicator of VH was reached at a lower pressure threshold in PG than in NPG or CG (p < 0.05). The perception was not different between NPG and CG (p > 0.05). Conclusions: The induction of typical abdominal discomfort in patients with IBS by the use of rectal barostat occurred predominantly in H. pylori infected patients and suggests that H. pylori infection may be involved in triggering VH in patients with IBS. Further studies in larger patient groups and after H. pylori eradication therapy are needed to confirm and extend this observation.

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Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response

Cited by 95 publications

References 19 publications

Sex differences in dietary coping with gastrointestinal symptoms

Sex differences in dietary coping with gastrointestinal symptoms

Padrão mioelétrico do cólon esquerdo no reflexo gastrocólico

<i>H. pylori</i> Infection and Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome

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