Participation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumors

Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis

“…Several studies have shown that the cytokine profile in saliva, lesions, and serum of patients with OLP differs from that seen in healthy individuals (Dan et al, ; de Brito Monteiro et al, ; Kaur & Jacobs, ; Kondo & Urisu, ; Liu et al, ; Lu et al, ; Malekzadeh et al, ; Pekiner et al, ; Piccinni et al, ; Simark‐Mattsson et al, ; Wang et al, ; Zhou et al, ). In this study, we found that the serum levels of IL‐6 were higher in the patients than in the healthy control subjects and in accordance with previous findings that also found an association between levels of IL‐6 and the stages of OLP (Abdel‐Haq et al, ; Kaur & Jacobs, ).…”

“…Changes in the expression of cytokines may reflect the extent of immune dysregulation and various roles of cytokines in the pathogenesis of inflammatory diseases such as OLP (Lu, Zhang, Sun, Du, & Zhou, ; Moudgil & Choubey, ). A number of studies have shown that the expression pattern of various inflammation‐related cytokines, including tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ, and interleukin (IL‐)‐1, 2, 4, 5, 6, 8, 10, 12, 17, 22, in lesions, saliva, serum, and peripheral blood mononuclear cells (PBMCs) from patients with OLP differs from that seen in healthy control subjects (Dan et al, ; de Brito Monteiro et al, ; Kaur & Jacobs, ; Kondo & Urisu, ; Liu et al, ; Malekzadeh, Robati, Yousefimanesh, Ghafourian Boroujerdnia, & Nadripour, ; Pekiner, Demirel, Borahan, & Ozbayrak, ; Piccinni et al, ; Simark‐Mattsson et al, ; Wang, Zhou, Fu, Wang, & Zhou, ; Zhou et al, ). TNF‐α is one the most studied cytokines in OLP and is believed to play an important role in the immune regulation of OLP (Pezelj‐Ribaric et al, ).…”