1984
DOI: 10.1038/312646a0
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Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

Abstract: The cellular tumour antigen p53 is found at elevated levels in a wide variety of transformed cells (for reviews see refs 1, 2). Very little is yet known about the precise relationship of p53 to malignant transformation. Although the increase in p53 levels could be a secondary by-product of the transformed state, it is equally possible that p53 is actively involved in altering cellular growth properties, especially as it has been implicated in the regulation of normal cell proliferation. We sought to test wheth… Show more

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Cited by 679 publications
(357 citation statements)
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“…In fact, a number of properties initially attributed to p53 protein, including the ability to immortalize cells (Jenkins et al, 1984) and to transform primary rat embryo ®broblasts in cooperation with ras (Eliyahu et al, 1984;Parada et al, 1984) suggested that it was a dominantly acting oncogene. Mutation of p53 gene was reported to enhance its transformation e ciency, a ®nding which ®tted with the hypothesis that p53 was a cellular oncogene that could be activated by mutation (Jenkins et al, 1985).…”
Section: From Oncogene To Tumour Suppressor Genementioning
confidence: 99%
“…In fact, a number of properties initially attributed to p53 protein, including the ability to immortalize cells (Jenkins et al, 1984) and to transform primary rat embryo ®broblasts in cooperation with ras (Eliyahu et al, 1984;Parada et al, 1984) suggested that it was a dominantly acting oncogene. Mutation of p53 gene was reported to enhance its transformation e ciency, a ®nding which ®tted with the hypothesis that p53 was a cellular oncogene that could be activated by mutation (Jenkins et al, 1985).…”
Section: From Oncogene To Tumour Suppressor Genementioning
confidence: 99%
“…Exogenous expression of cloned TP53 was shown to immortalize cells (Jenkins et al, 1984) and endow them with overt tumorigenic potential in mice Eliyahu et al, 1985). Furthermore, cloned TP53 could co-operate with Ha-ras to transform normal rat embryonic fibroblasts (Eliyahu et al, 1984;Parada et al, 1984). All this evidence strengthened the notion that p53 possesses cancer-promoting properties.…”
Section: Discovery Of Tp53 Mutations In Cancermentioning
confidence: 68%
“…THE TP53 GENE TP53 was first identified in 1979 as a gene encoding a protein that complexes to the large T antigen of SV40 (Lane and Crawford, 1979;Linzer and Levine, 1979). A number of properties initially assigned to the TP53 protein, including the ability to immortalize cells (Jenkins et al, 1984) and to transform primary rat embryo fibroblasts in cooperation with ras (Eliyahu et al, 1984;Parada et al, 1984), indicated that it was a dominantly acting oncogene. Mutation to TP53 was found to enhance its transformation efficiency, a finding compatible with the hypothesis that TP53 is a cellular oncogene that can be activated by mutation (Jenkins et al, 1985).…”
mentioning
confidence: 99%