Participation of the Monoaminergic System in the Antidepressant-Like Actions of Estrogens: A Review in Preclinical Studies

López‐Rubalcava, Carolina; Vega‐Rivera, Nelly Maritza; Páez-Martínez, Nayeli; Estrada‐Camarena, Erika

doi:10.5772/37895

Cited by 2 publications

(1 citation statement)

References 111 publications

(113 reference statements)

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“…There is evidence that ERβ activation promotes changes in the 5-HT-1A receptor’s sensitivity [ 38 ], a receptor involved in the antidepressant-like effect of E2 [ 31 ]. Considering this information, it is possible that the metabolites of the ellagitannins induce their antidepressant-like effect through the activation of estrogen receptors, which modulate the serotonergic system activity [ 39 ]. In fact, our results reveal that the antidepressant-like effect produced by the AE-PG is reversed with the administration of tamoxifen, a non-specific estrogen receptor antagonist [ 40 ], confirming the participation of ER in this effect.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Pomegranate Alone or in Combination with Citalopram Produces Antidepressant-Like Effects in an Animal Model of Menopause: Participation of Estrogen Receptors

Valdés-Sustaita

López‐Rubalcava

González-Trujano

et al. 2017

IJMS

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It has been reported that the aqueous extract of pomegranate (AE-PG) has polyphenols with estrogenic-like activities. The present work determines if AE-PG alone or in combination with the selective serotonin reuptake inhibitor, citalopram, has antidepressant-like effects. It was also analyzed the participation of estrogen receptors (ER). AE-PG (0.1, 1.0, 10, or 100 mg/kg) was evaluated in ovariectomized female Wistar rats subjected to the forced swimming test. The effects induced by AE-PG were compared with those of citalopram (2.5, 5.0, 10, and 20.0 mg/kg) and 17β-estradiol (E2; 2.5 5.0, and 10 μg/rat). Likewise, the combination of suboptimal doses of AE-PG (0.1 mg/kg) plus citalopram (2.5 mg/kg) was evaluated. To determine if ER participates in the antidepressant-like action of pomegranate, the estrogen antagonist tamoxifen (15 mg/kg) was administered with AE-PG (1 mg/kg). AE-PG produced antidepressant-like actions with a similar behavioral profile induced by citalopram and E2. Suboptimal doses of citalopram plus AE-PG produced antidepressant-like effects. Tamoxifen was able to block AE-PG’s antidepressant-like actions. These results confirm the participation of ER in AE-PG’s antidepressant-like effects. Furthermore, the additive effects observed with the combined treatment of AE-PG plus citalopram could be advantageous in the treatment of depressive disorders, such as menopause.

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Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Pomegranate Alone or in Combination with Citalopram Produces Antidepressant-Like Effects in an Animal Model of Menopause: Participation of Estrogen Receptors

Valdés-Sustaita

López‐Rubalcava

González-Trujano

et al. 2017

IJMS

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To quit or not: Vulnerability of women to smoking tobacco

Park

Lee

et al. 2015

Journal of Environmental Science and Health, Part C

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Tobacco smoking is currently on the rise among women, and can pose a greater health risk. In order to understand the nature of the increase in smoking prevalence among women, we focused on the vulnerability of women to smoking behaviors--smoking cessation or tobacco addiction--and performed a systematic review of the socioeconomic and intrinsic factors as well as tobacco ingredients that affect women's susceptibility to smoking tobacco. We observed that nicotine and other tobacco components including cocoa-relatives, licorice products, and menthol aggravate tobacco addiction in women rather than in men. Various genetic and epigenetic alterations in dopamine pathway and the pharmaco-kinetics and -dynamic factors of nicotine also showed potential evidences for high susceptibility to tobacco addiction in women. Therefore, we suggest systemic approaches to prevent tobacco smoking-related health risks, considering gene-environment-gender interaction.

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Participation of the Monoaminergic System in the Antidepressant-Like Actions of Estrogens: A Review in Preclinical Studies

Cited by 2 publications

References 111 publications

Aqueous Extract of Pomegranate Alone or in Combination with Citalopram Produces Antidepressant-Like Effects in an Animal Model of Menopause: Participation of Estrogen Receptors

Aqueous Extract of Pomegranate Alone or in Combination with Citalopram Produces Antidepressant-Like Effects in an Animal Model of Menopause: Participation of Estrogen Receptors

To quit or not: Vulnerability of women to smoking tobacco

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