Participation of the prefrontal cortices in prospective memory: evidence from a PET study in humans

Okuda, Jun; Fujii, Toshikatsu; Yamadori, Atsushi; Kawashima, Ryuta; Tsukiura, Takashi; Fukatsu, Reiko; Suzuki, Kyoko; Ito, Masako; Fukuda, Hiroshi

doi:10.1016/s0304-3940(98)00628-4

Cited by 238 publications

(179 citation statements)

References 12 publications

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“…On the one hand, univariate analyses indicated strong engagement of RLPFC while participants stored PM intentions, consistent with previous neuroimaging and neuropsychological studies indicating the involvement of this region in PM (Okuda et al, 1998;Burgess et al, 2000Burgess et al, , 2001Burgess et al, , 2003Simons et al, 2006;West, 2008;Gilbert et al, 2009;Reynolds et al, 2009;Uretzky and Gilboa, 2010). However, it was not possible to decode the content of those intentions from patterns of activity within RLPFC (unlike widespread posterior brain regions).…”

Section: Functional Connectivity Analysissupporting

confidence: 84%

“…The idea that RLPFC plays a "content-free" role in PM is congruent with repeated findings of RLPFC activation in PM paradigms using a wide variety of different stimulus types and task demands (Okuda et al, 1998;Burgess et al, 2001Burgess et al, , 2003Simons et al, 2006;Gilbert et al, 2009). Furthermore, the present The table shows peak coordinates of regions from which it was possible to decode the forthcoming PM cue (word vs picture) or the forthcoming PM response (third vs fourth finger) during PM storage periods with significantly greater accuracy than the corresponding baseline storage periods.…”

Section: Discussionsupporting

confidence: 65%

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Decoding the Content of Delayed Intentions

Gilbert¹

2011

J. Neurosci.

130

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Rostrolateral prefrontal cortex (RLPFC) plays a key role in our ability to postpone the execution of intended behaviors until after another activity has been performed. However, it is poorly understood in computational terms. One crucial question is whether RLPFC represents the content of delayed intentions or plays a nonspecific role. In this human functional magnetic resonance imaging study (n ϭ 32), RLPFC was active while participantsstoreddelayedintentionsduringadistractingongoingtask.Multivariateanalysisshowedthattheintendedcueforfutureactionand the intended behavior could be decoded from distinct posterior brain regions. However, the content of intentions could not be decoded from RLPFC itself. Functional connectivity analysis showed that RLPFC increased its coupling with content-representing regions during intention storage. Furthermore, trials with relatively high RLPFC activity were associated with enhanced decoding. Thus, RLPFC may enable realization of delayed intentions via interactions with posterior brain regions, which represent their content.

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Section: Functional Connectivity Analysissupporting

confidence: 84%

Section: Discussionsupporting

confidence: 65%

Decoding the Content of Delayed Intentions

Gilbert¹

2011

J. Neurosci.

130

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“…The emerging evidence for the engagement of strategic processing in some aspects of ProM retrieval are consistent with the involvement of frontal or executive function in planning and in delayed implementation of plans or intentions (eg Shallice and Burgess, 1996;Burgess et al, 2003). Indeed, there is converging evidence from neuroimaging studies that Brodmann's area 10, within the rostral frontal cortex, has special significance in the maintenance (as opposed to the execution) of an intention (Burgess et al, 2001;Okuda et al, 1998;Burgess et al, 2003).…”

Section: Introductionmentioning

confidence: 67%

Comparable Effects of Nicotine in Smokers and Nonsmokers on a Prospective Memory Task

Rusted

Trawley

2005

Neuropsychopharmacol

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In a double-blind placebo-controlled study, we examined the effect of nicotine, a cholinergic agonist, on performance of a prospective memory (ProM) task in young adult volunteers. Volunteers were required to complete an ongoing lexical decision task while maintaining the ProM task (responding with a different button press to items containing particular target letters). Half of the volunteers were smokers, half were nonsmokers. Half of each group received a single dose (1 mg) of nicotine nasal spray before completing the task; the remaining volunteers received a matched inactive placebo spray. Nicotine improved performance on the ProM task when volunteers were able to devote resources to that task. Under a variant procedure, where volunteers completed a concurrent auditory monitoring task, ProM performance was impaired under nicotine. Results are discussed in terms of the resource model of ProM, and the arousal model of drug effects. The data suggest that ProM under the conditions tested here is a resource-needy process, and that nicotine can improve performance by increasing available resources. Increased working memory demands that encourage redirection of resources may impair ProM performance, but the conditions under which these deficits emerge depend upon the subjective allocation of resources across tasks, rather than resource availability per se. Neuropsychopharmacology (2006) 31, 1545-1549.

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“…Okuda and colleagues found that future thinking (particularly for temporally distant events) was associated with activity in the anteromedial prefrontal cortex, a region associated with both autobiographical memory retrieval (Svoboda, McKinnon, & Levine, 2006) and prospective memory (Burgess, Scott, & Frith, 2003;Okuda et al, 1998). Moreover, the medial temporal lobes-known to mediate the retrieval of past events (Squire & Zola-Morgan, 1991)-were activated for both past and future events.…”

Section: Discussionmentioning

confidence: 99%

The temporal distribution of past and future autobiographical events across the lifespan

2006

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Knowledge and awareness of past and future autobiographical events may be mediated by a common system that supports intentional, goal-directed behavior. The purpose of this study was to assess the correspondence of past and future autobiographical thought. In Experiment 1, 300 undergraduates aged 19 years generated and assigned dates to past and future autobiographical events. The temporal distribution of past events replicated a power function for retention as has been described in past research. The intention function of future autobiographical events fit the inverse of this same power function, reflecting a temporality of past and future mental time travel centered around the present moment. In Experiment 2, these findings were extended to young, middle-aged, and older groups. These data provide empirical support for the notion that thinking outside of "now" is mediated by a common system, regardless of whether one is thinking about the past or the future.

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Participation of the prefrontal cortices in prospective memory: evidence from a PET study in humans

Cited by 238 publications

References 12 publications

Decoding the Content of Delayed Intentions

Decoding the Content of Delayed Intentions

Comparable Effects of Nicotine in Smokers and Nonsmokers on a Prospective Memory Task

The temporal distribution of past and future autobiographical events across the lifespan

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