Participation of the prolactin-releasing peptide-containing neurones in caudal medulla in conveying haemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus

Uchida, Katsuya; Kobayashi, Daisuke; Das, Gopal D.; Onaka, Tatsushi; Inoue, Kinji; Itoi, Keiichi

doi:10.1016/j.neures.2010.07.1255

Cited by 5 publications

(7 citation statements)

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“…Consistent with the present data suggesting that PrRP activates SON vasopressin neurones, microinjections of PrRP into the PVN have been reported to facilitate vasopressin release into the peripheral circulation . Haemorrhage activates PrRP neurones in the ventrolateral medulla and vasopressin neurones in the hypothalamus . It is interesting to speculate that PrRP neurones in the ventrolateral medulla might play a role in activation of vasopressin neurones following haemorrhage.…”

Section: Discussionsupporting

confidence: 92%

“…Vasopressin released within the hypothalamus has been shown to modulate activity of vasopressin neurones . Consistent with the present data suggesting that PrRP activates SON vasopressin neurones, microinjections of PrRP into the PVN have been reported to facilitate vasopressin release into the peripheral circulation . Haemorrhage activates PrRP neurones in the ventrolateral medulla and vasopressin neurones in the hypothalamus .…”

Section: Discussionsupporting

confidence: 91%

“…Food intake or CCK administration activates PrRP‐synthesising neurones in the nucleus tractus solitarii (NTS), whereas fasting reduces the amount of PrRP mRNA in the NTS . Some of the PrRP‐synthesising neurones project to magnocellular oxytocin neurones in the SON and to neurones in the PVN . The administration of PrRP facilitates oxytocin release into peripheral blood .…”

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confidence: 99%

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Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake

Yamashita

Takayanagi

Yoshida

et al. 2013

J Neuroendocrinology

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Food intake activates neurones expressing prolactin-releasing peptide (PrRP) in the medulla oblongata and oxytocin neurones in the hypothalamus. Both PrRP and oxytocin have been shown to have an anorexic action. In the present study, we investigated whether the activation of oxytocin neurones following food intake is mediated by PrRP. We first examined the expression of PrRP receptors (also known as GPR10) in rats. Immunoreactivity of PrRP receptors was observed in oxytocin neurones and in vasopressin neurones in the paraventricular and supraoptic nuclei of the hypothalamus and in the bed nucleus of the stria terminalis. Application of PrRP to isolated supraoptic nuclei facilitated the release of oxytocin and vasopressin. In mice, re-feeding increased the expression of Fos protein in oxytocin neurones of the hypothalamus and bed nucleus of the stria terminalis. The increased expression of Fos protein in oxytocin neurones following re-feeding or i.p. administration of cholecystokinin octapeptide (CCK), a peripheral satiety factor, was impaired in PrRP-deficient mice. CCK-induced oxytocin increase in plasma was also impaired in PrRP-deficient mice. Furthermore, oxytocin receptor-deficient mice showed an increased meal size, as reported in PrRP-deficient mice and in CCKA receptor-deficient mice. These findings suggest that PrRP mediates, at least in part, the activation of oxytocin neurones in response to food intake, and that the CCK–PrRP–oxytocin pathway plays an important role in the control of the termination of each meal.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

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Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake

Yamashita

Takayanagi

Yoshida

et al. 2013

J Neuroendocrinology

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“…Recently, Uchida et al. (65) demonstrated the direct projection of the PrRP neurones to the PVN as well as their activation by hypotensive hemorrhage. There was an interaction between PrRP and noradrenaline in the PVN for ACTH and vasopressin secretion, suggesting a functional role of the neuropeptide, co‐expressed in medullary NAergic neurones, for regulating the neuroendocrine neurones in the hypothalamus (Fig.…”

Section: The Medullary Nuclei As the Source Of Naergic Inputs To The mentioning

confidence: 99%

The Brainstem Noradrenergic Systems in Stress, Anxiety and Depression

Itoi

Sugimoto

2010

J Neuroendocrinology

181

129

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The locus coeruleus (LC) is regarded as a part of the central ‘stress circuitry’ because robust activation of the LC has been reported after stressful stimuli in experimental animals. A considerable amount of clinical evidence also suggests the relationship between the central noradrenergic (NAergic) system and fear/anxiety states or depression. However, previous animal studies have not been able to demonstrate unequivocally the involvement of the NAergic system in mediating fear or anxiety. The forebrain structures, including the hypothalamus, receive massive inputs from the medullary NAergic nuclei via the ventral NAergic bundle (VNAB). The VNAB has been implicated in the neuroendocrine stress axis mainly through its action on the corticotrophin‐releasing factor neurones in the paraventricular nucleus of the hypothalamus. Novel tools were introduced that are capable of disrupting the NAergic system more selectively and/or thoroughly than the neurotoxins employed in previous studies: the anti‐dopamine‐β hydroxylase (DBH)‐saporin is an immunotoxin that is taken up from nerve endings and disrupt the NAergic neurones in a retrograde manner. The genetically DBH‐depleted mice were also introduced, which lack endogenous noradrenaline. Owing to the rapid development of functional imaging technique, visualisation of the emotional phenomena has become possible in human subjects. Along with the advent of these technologies, endeavors have been continued to unravel the functional relevance of the central NAergic system to stress, anxiety and depression.

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“…It was proposed that ascending catecholaminergic pathways may mediate systemic stress responses [3]. Several neuropeptides are colocalized with noradrenaline (NA) in the brain stem, and these peptides may modulate the action of NA at the PVH [40]. The NAergic projection from the locus ceruleus (A6) is also postulated to convey signals to the PVH indirectly via the dorsal medial prefrontal cortex and stimulate CRF neurons by disinhibition of the GABAergic afferents to the PVH-CRF neurons [41].…”

Section: Regulatory Mechanisms For Crf Neurons In the Pvhmentioning

confidence: 99%

Exploring the Regulatory Mechanism of Stress Responses in the Paraventricular Nucleus of the Hypothalamus: Backgrounds and Future Perspectives of Corticotropin-Releasing Factor-Modified Yellow Fluorescent Protein-Knock-In Mouse

Itoi

2015

IIS

Self Cite

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Corticotropin-releasing factor (CRF) plays a central role in the stress response by regulating the hypothalamicpituitary-adrenal axis. In order to unravel unsolved issues underlying the regulatory mechanisms for CRF neurons, modified yellow fluorescent protein (Venus) gene was inserted into the CRF gene in frame, and CRF neurons were visualized by the Venus fluorescence. Venus expression is overlapped with CRF expression in most brain regions, including the paraventricular nucleus of the hypothalamus (PVH). This mouse is a useful tool especially for conducting electrophysiological recordings from CRF neurons. In the first half of the present review, the backgrounds of the generation of the mouse are described based on the previous literature: first, the anatomical distribution of CRF-immunoreactive neurons in the rat brain is overviewed, and then the knowledge on the electrophysiological properties of the parvocellular neuroendocrine neurons that constitute a subpopulation of neurons in the PVH (including PVH-CRF neurons) is described. These sections may help the readers in understanding the purpose of generating the CRF-Venus mouse. In the second half of the manuscript, the distribution of Venus-expressing neurons is characterized in the CRF-Venus mouse, and preliminary results of electrophysiological recordings from the Venus-expressing neurons are shown. CRF driver mouse lines are also referred to as a means for the CRF neuron-selective gene transfer or targeting. Novel mouse lines may serve as tools for disclosing the regulatory mechanisms for CRF neurons in the PVH, as well as other brain regions.

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Participation of the prolactin-releasing peptide-containing neurones in caudal medulla in conveying haemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus

Cited by 5 publications

References 0 publications

Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake

Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake

The Brainstem Noradrenergic Systems in Stress, Anxiety and Depression

Exploring the Regulatory Mechanism of Stress Responses in the Paraventricular Nucleus of the Hypothalamus: Backgrounds and Future Perspectives of Corticotropin-Releasing Factor-Modified Yellow Fluorescent Protein-Knock-In Mouse

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